新疆苦豆子种子中生物碱类化学成分的研究  

Chemical Constituents from the Seeds of Sophora Alopecuroides L.

作　　者：高红英[1] 李国玉[1] 王航宇[1] 王金辉[1,2] 

机构地区：[1]石河子大学药学院/新疆特种植物药资源重点实验室,石河子832002 [2]沈阳药科大学中药学院,沈阳110016

出　　处：《石河子大学学报（自然科学版）》2011年第1期75-78,共4页Journal of Shihezi University(Natural Science)

基　　金：中国科学院西部之光课题(RCPY200707)

摘　　要：采用硅胶柱层析法、氧化铝柱层析法、Sephadex LH-20柱色谱法,以及重结晶等方法对新疆苦豆子种子中生物碱类化学成分进行研究,根据化合物的理化性质和光谱数据鉴定其结构。结果从新疆苦豆子种子中分离得到4个化合物,分别鉴定为9α-羟基苦参碱(Ⅰ)、苦参碱(Ⅱ)、槐定碱(Ⅲ)、氧化苦参碱(Ⅳ)。其中化合物Ⅰ为首次从本植物中分离得到。To study the chemical constitutes from the seeds of Sophora alopecuroides L,compounds were separated by colomn chromatography on silica gel,aluminium oxide and Sephadex LH-20.The structures were elucidated by spectral analyses and physicochemical properties.Four compounds were obtained and were identified as 9α-hydroxymatrine（Ⅰ）,Matrine（Ⅱ）,Sophoridine（Ⅲ）,Oxymatrie（Ⅳ）.Compound Ⅰ was isolated from the seeds of Sophora alopecuroides L.for the first time.

关 键 词：苦豆子 生物碱 结构鉴定 

分 类 号：R93[医药卫生—生药学]