混合皮肤移植中角朊细胞的免疫抑制功能研究进展  

Relative Research of Immuno-suppression Induced by Keratinocytes in Intermingled Skin Grafting Application

作　　者：柏莹[1] 曹颖平[1] 

机构地区：[1]福建医科大学附属协和临床医学院,福州350001

出　　处：《医学综述》2011年第3期343-345,共3页Medical Recapitulate

摘　　要：皮肤移植是烧伤治疗的重要手段,运用混合皮肤移植技术,即异体皮中嵌入自体皮片,可缓解移植排斥反应,并加速上皮化速度。国内外学者进行体内外实验研究,发现此抑制作用是由自体皮中的角朊细胞引起的。关于自体角朊细胞介导免疫耐受的机制,主要与其自身表达共刺激分子B7-H1,与受体PD-1相互作用,以及诱导产生CD4+CD2+5调节性T细胞等有关。Skin-grafting is an important method in the burn cure.It is found that intermingled skin grafting using autologous skin islets inlaid in allogeneic skin sheets could delay graft rejection and improve epithelization.Autologous keratinocytes played an key role in the local immuno-suppression tested by various experiments in vivo and vitro.While B7-H1 expression on keratinocytes and its interaction with PD-1,the induced CD4＋CD25＋regulatory T cell（CD4＋CD25＋Treg）,all this contributed to the immune tolerance.

关 键 词：角朊细胞 混合皮肤移植 B7-H1 PD-1 免疫抑制 

分 类 号：R318.06[医药卫生—生物医学工程] R751.05[医药卫生—基础医学]