减少对血流干扰的双叶机械心脏瓣膜的新设计  

A New Design of Bileaflet Heart Valve to Eliminate the Blood Flow Disturbance

作　　者：张祖仁[1] 王一山[1] 

机构地区：[1]上海第二医科大学附属仁济医院,200001

出　　处：《中国医疗器械杂志》1999年第5期249-251,257,共4页Chinese Journal of Medical Instrumentation

基　　金：卫生部科学研究基金

摘　　要：目前临床使用的双叶瓣的主要问题是血栓栓塞和与抗凝治疗有关的出血，其缺陷在于碟片开启时两个碟片将瓣膜的整个血流通道分隔成三个较小的血流通道。在这种受阻隔的血流通道中，产生容易诱发血栓形成的高剪应力区、紊流和滞流区。作者研制的双叶瓣在碟片开启时没有任何支架或碟片分隔瓣膜的血流通道，使血流与天然心脏瓣膜中的相类似，有利于显著减少瓣膜对血流的干扰，降低血栓形成，从而可减少病人对抗凝治疗的依赖程度。The major problems of current clinically-used bileaflet heart valves are thromboembolism and hemorrhage related to anticoagulants.These bileaflet heart valves are considered as being unsatifactory,because in the open position,two leaflets divide the ring orifice of the valve into three regions.In this obstructive orifice,the high turbulent shear stresses and the region of flow separation and stagnation all give rise to the occurrence of thrombosis.In our design of bileaflet heart valve, in the open position,no structural component or leaflet divides the ring orifice of the valve.Our bileaflet heart valve has the best possibilities for creating more natural blood flow Pattern which could deccease or eliminate the blood flow disturbance so as to reduce the risk of thrombosis and the needs for anticoagulation therapy.

关 键 词：机械心脏瓣膜 血栓形成 双叶瓣膜 设计 

分 类 号：R318.11[医药卫生—生物医学工程]