781例15～50岁健康者骨密度与影响因素分析  

Analysis of Bone Mineral Density and Relevant Factors in 781 Healthy People Aged 15 to 50

作　　者：秦林林[1] 陈金标[1] 葛崇华[1] 马海波[1] 张卫[1] 肖艳霞[1] 包安德[1] 

机构地区：[1]北京市中日友好医院临床医学研究所同位素研究室,100029

出　　处：《中华预防医学杂志》1999年第5期282-285,共4页Chinese Journal of Preventive Medicine

基　　金：联合国国际原子能机构赞助

摘　　要：目的进一步确定骨峰形成的年龄和影响峰值骨量、骨密度的因素，为预防老年骨质疏松寻找有效途径。方法对781例15～50岁健康人进行骨密度测定和生活因子调查，对生活因子与骨密度的关系进行多元回归分析，确定危险因子和有利因子。结果体重每增加10kg，男性不同部位骨密度值将相应升高0．028～0．056g／cm2，女性升高0．050～0．086g／cm2；青少年时期男性运动量每增加1个等级，骨密度在不同部位升高0．034～0．078g／cm2，女性腰椎和全身约升高0．035g／cm2；15～24岁的男性腰椎骨密度与饮酒总量呈负相关；25～50岁者全身和腰椎骨密度与抽烟总量呈负相关；女性腰椎骨密度与初潮呈负相关；女性平均母乳喂养时间与腰椎骨密度呈正相关。结论加强青少年时期体育锻练，能有效提高峰值骨量，保持适当体重和减少烟、酒摄入量有利于预防老年骨质疏松。Objective To determine further the age to form peak bene me (PBM) and the factor influ-eocing it and bene theneral density (BMD) and to find an dehve way to prevent from osteoporosis in the elderly.Methods BMD was meased in 781 people aged 15 to 50 years and relevant factors in lifestye were investigated. Multivariate regression was used to analyze the relationship between BMD and lifestyes and to identify both riskand benefit factors for osteoporosis. Results For every ten-kilogram increase in body weight, BMD at varied sitesincreased by an amount of 0.028-0.056g/cm2 for males and 0.050-0.086g/cm2 for females, respectively.During their adolescence for males, for every increase of one grade in physical exercise, BMD at vdried sites increasedby an amount of 0.034-0.078g/cm2 in males and BMD at lumbar vertebra in males aged 15-24 correlated negatively with their total amount of alcohol drinking, and that at lumbar vertebra and of the whale body increased byabout 0.035g/cm2 in females, which correlated negatively with their total amount of cigarette smoking. FemaleBMD at lumbar vertebra correlated revemely with their age of menarche and correlated positively with their averagetime of breast feeding.Conclusion Increase in physical exercise during puberty could increase PBM for the adolescents and keeping adequate body weight and reducing cigarette smoking and alcohol drinking would benefit forthe prevention from age-related osteoporsis.

关 键 词：骨密度 骨质疏松 多元分析 预防 

分 类 号：R68[医药卫生—骨科学] R681.01[医药卫生—外科学]