丙型肝炎病毒母婴传播及机制研究  

Study on the Mother to Infant Transmission of Hepatitis C Virus and its Mechanism

作　　者：袁明[1] 陆志檬[1] 赵力新[1] 李梁 孙正伟 张东华[1] 

机构地区：[1]上海第二医科大学附属瑞金医院传染科,200025

出　　处：《上海第二医科大学学报》1999年第5期389-391,397,共4页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：卫生部基金!94-2-231;上海市科委资助!934912019

摘　　要：目的对丙型肝炎病毒母婴传播及其机制进行研究。方法联合检测抗-HCV和HCV-RNA确定孕妇和婴儿丙型肝炎病毒（HCV）感染，分析HCV基因型和定量检测孕妇血清中HCV，研究HCV的母婴传播及其影响因素。结果对610名孕妇进行了研究，孕妇HCV感染率为295％（18／610）。对感染HCV的孕妇所生18名婴儿随访12个月，其中5名婴儿感染了HCV。HCV母婴传播率为278％（5／18）。所有孕妇和婴儿均为HCV基因型1b感染。孕妇血清中存在较低水平的HCV（≤14.11×105／ml）。结论孕妇血清HCV低滴度时可以传播HCV于其婴儿。依靠执-HCV和HCV-RNA检测可明确孕妇和婴儿HCV感染，联合检测抗-HCV和HCV-RNA对确定HCV感染有一定的应用价值。Objective The mother to infant transmission of HCV was prospectively investigated. Methods Hepatitis C virus(HCV) infection was tested by the combination assay of anti- HCV and HCV - RNA. 610 pregnant women were investigated for HCV infection, and infants from HCV infected mothers were followed up at birth, 3, 6, 9, 12 months after birth to investigate HCV infection. HCV genotypes were detected in all persons with HCV- RNA positive. HCV was quantified by branch DNA signal amplification assay (bDNA) in pregnant women. Results Among 610 pregnant women, 18 infected HCV, the infection rate of HCV in pregnant women was 2.95% (18/610). Five of 18 infants from 18 HCV infected mothers infected HCV, they had no history of operation, or blood transfusion and other risk exposure to HCV, so the HCV infection was from their mothers, the rate of HCV transmission from mother to infant was 27.8%(5/18). HCV genotype 1b was found in 16 pregnant women with HCV - RNA positive, 5 infants and their mothers had the same HCV genotype(1b) infection. All pregnant women infected HCV have low HCV titer in serum. Conclusion In this research, it was noted that HCV could be vertically transmitted from mother to infant even if mother had low serum HCV titer (<14.11 × 105/ml). The combination assay of anti- HCV and HCV - RNA was valuable in investigating the HCV infection in pregnant women and the transmission of HCV from mother to infant. It has potential value in diagnosing HCV infection in other population.

关 键 词：丙型肝炎病毒 母婴传播 基因型 

分 类 号：R512.63[医药卫生—内科学]