妊高征尿系列微量蛋白检测的意义  

The Values of Testing the Urine Retinal Binding Protein and Microprotein in Cases with Pregnancy Induced Hypertension

作　　者：黄健[1] 张淑景[1] 刘国明[2] 

机构地区：[1]上海第二医科大学附属瑞金医院妇产科,200025 [2]上海第二医科大学科技中心实验室,200025

出　　处：《上海第二医科大学学报》1999年第5期423-425,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的检测尿视黄醇结合蛋白（RBP）、N-乙酸-β-D氨基葡萄糖着酶（NAG）、Alb和IgG值来探讨妊高征患者肾功能状态。方法对51例好高征患者（轻度19例，中度和重度各16例）进行尿系列微量蛋白的测定，包括RBP，NAG，A1b和IgG。各型妊高证分别与正常孕妇组（20例）比较。结果轻度妊高征与正常孕妇组比较显BP有非常显著差异（P＜0.01），Alb和NAG有显著差异（P＜0.05），IgG无显著差异（P＞0.05）。中度和重度妊高征组与正常孕妇组对照：四项参数均有非常显著差异（P<0.001）。RBP和NAG是肾小管损伤的标志。站台妊高征时有肾小管和肾小球损害。RBP与Alb排量增加可作为妊高征患者早期肾小管和肾小球损害的指标，也可作为妊高征患者病情转归的一个指标。Objective To evaluate renal function in pregnancy induced hypertension by detecting urine RBP, NAG, Alb and IgG. Methods 51 cases of pregnancy induced hypertension syndrome, PIH (19 cases of mild, 16 moderate or severe) are grouped in order to test the values of urine microproteins, including RBP, NAG, Alb and IgG. The values of each PIH group are compared with those of the control group respectively (20 cases).Results An obviously significant difference was found in RBP (P<0.01), while significant differences in Alb and NAG (P<0.05) between the mild PIH group and control group. There is no significant difference in IgG between the two groups (P>0.05). When comparing the moderate or severe PIH group with the control group, obviously significant differences are found in the four parameters (P<0.01). RBP and NAG are the markers of renal tubules lesion. As Alb has a less molecular value, its value rises significantly even in mild PIH cases. Conclusion Renal tubules and glomeruli are impaired in PIH. Elevated values of RBP and Alb might be markers for renal tubules and glomeruli lesion in early stage PIH syndrome and might be markers for prognosis in these cases.

关 键 词：妊娠高血压 综合征 尿 微量蛋白 RBP 

分 类 号：R714.246[医药卫生—妇产科学]