胰岛素抵抗和认知功能障碍  

Insulin resistance and cognitive impairment

作　　者：韩亭亭[1] 胡耀敏[1] 刘伟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,200127

出　　处：《国际内分泌代谢杂志》2011年第1期31-34,共4页International Journal of Endocrinology and Metabolism

基　　金：基金项目：国家自然科学基金资助项目（30670988）;浦东新区社会发展局卫生科技项目（PW2008D-1）

摘　　要：近年来阿尔茨海默病（AD）已被学术界称为“3型糖尿病”，这是由于AD具有和糖尿病相似的发病机制，即大脑胰岛素缺乏和胰岛素抵抗。糖尿病通过“肝-脑轴”将外周胰岛素抵抗向中枢“传递”，从而促进认知功能障碍的发生，是AD重要的危险因素，而这种“传递”作用甚至可能在糖尿病前期——葡萄糖调节受损状态就已经存在。在认知功能障碍的防治上，改善胰岛素抵抗成为新的研究方向。In recent years,Alzheimer＇s disease has represented ＂type 3 diabetes mellitus （T3DM）＂. T3DM corresponds to brain insulin deficiency and insulin resistance that is similar to the pathogenesis of diabetes. Diabetes mellitos may ＂transmit＂ insulin resistance from peripheral tissue to central nervous system via a ＂ liver-brain axis＂ to promote the development of cognitive impairment. Thus diabetes is an important risk factor of Alzheimer＇s disease. And it is likely that the function of ＂transmission＂ has existed at the stage of pre-diabetes-impaired glucose regulation. The strategy of improving insulin resistance has provided a new direction to prevent and cure cognitive impairment.

关 键 词：胰岛素抵抗 认知功能障碍 阿尔茨海默病 糖尿病 葡萄糖调节受损 

分 类 号：R587.1[医药卫生—内分泌]