腹腔镜联合药物治疗中重度子宫内膜异位症疗效分析  

Clinical Study of Laparoscopic Operations Combined with Endocrinal Therapy for the Treatment of Mild and Severe Endometriosis

作　　者：姚吉龙[1] 覃春容[1] 段纯[1] 潘利云[1] 刘庆芝[1] 张丽[1] 

机构地区：[1]南方医科大学附属深圳市妇幼保健院妇科,广东深圳518028

出　　处：《肿瘤预防与治疗》2011年第2期96-98,共3页Journal of Cancer Control And Treatment

基　　金：深圳市科技计划项目 (200802066)

摘　　要：目的:探讨内美通及诺雷德用于中重度盆腔子宫内膜异位症腹腔镜术后辅助治疗的疗效及安全性。方法:对152例Ⅲ期～Ⅳ期子宫内膜异位症在腹腔镜术后随机分为应用内美通组、诺雷德组及未用药组,比较三组患者术后复发率、妊娠率及不良反应的发生率。结果:本组患者术后均病理诊断证实为子宫内膜异位症。至随访时,内美通、诺雷德组复发率分别为12.00%、12.90%,低于未用药组的30.00%(P<0.05)。内美通、诺雷德组妊娠率分别为28.57%、44.19%,未用药组17.86%,诺雷德组术后妊娠率较未用药组高。结论:内美通、诺雷德用于中重度盆腔子宫内膜异位症腹腔镜术后的治疗均能显著降低内膜异位症复发率,术后使用诺雷德妊娠率较高。Objective： To study the clinical value of laparoscopic operations combined with endocrinal therapy on the treatment of mild and severe endometriosis. Methods： Laparoseopie operations were completed in 152 cases of mild and severe endometriosis. All post-operative cases were divided into 3 groups：50 cases were treated with synthesis progesterone（gestfinone） ,62 with ganodotropin releasing hormone-analogue（GnRHa） ,and 28 without endoerlnal therapy. The recurrence rate, following pregnancy rate and side effects were compared. Results： The recurrence rates were 12.0%, 12. 9% and 30.0% respectively in gestrinone, GnRHa group and the group without endocfinal therapy. The pregnancy rate were 28.57% ,44. 19% and 17. 86% respectively. There was significant difference in recurrence rates and pregnancy rates among three group. Conclusion： Laparoseopic operations combined with post-operative endocrinal therapy have significant importance for enhancement of fecundity in infertile women with mild and severe endometroiosis. The treatment of GnRH-A with laparoscopie operation can increase pregnancy rate.

关 键 词：子宫内膜异位症 腹腔镜 内美通 诺雷德 

分 类 号：R711.71[医药卫生—妇产科学] R713[医药卫生—临床医学]