地塞米松在预防新生儿湿肺中的应用价值  

Value of prenatal dexamethasone treatment in the prevention of Wet lung syndrome of the newborn

作　　者：戴洁[1] 秦洁[1] 郑戈[1] 

机构地区：[1]温州医学院附属第三医院妇产科,浙江瑞安325200

出　　处：《中国医师进修杂志》2011年第4期29-31,共3页Chinese Journal of Postgraduates of Medicine

基　　金：浙江省温州市科技局社会发展项目（2009S0312）

摘　　要：目的探讨足月选择性剖宫产中地塞米松对新生儿湿肺的预防效果。方法按照随机数字表法将孕周〈39周足月选择性剖宫产孕妇200例分为试验组和对照组各100例，试验组产前予地塞米松24h至7d，每次6mg肌肉注射，每12h1次，共4次。对照组予0．9％氯化钠肌肉注射，方法同上。采集两组孕妇的一般临床资料、新生儿湿肺的发生情况。结果新生儿湿肺发生率t试验组1％（1／100），对照组9％（9／100）；重症新生儿湿肺发生率：试验组1％（1／100），对照组2％（2／100）；并发症：试验组0例，对照组1例a试验组新生儿湿肺发生率和重症新生儿湿肺发生率明显低于对照组（P=0．009、0．049），同时并发症少。结论产前地塞米松干预足月选择性剖宫产孕妇，能减少新生儿湿肺的发生率，降低重症新生儿湿肺及并发症的发生率。Objective, To explore the effect of the prenatal dexamethasone treatment on the prevention of wet lung syndrome in the newborn of elective caesarean section at term. Methods Two hundred cases of elective caesarean section at term （the gestation age was less than 39 weeks） were divided into observation group and control group,with 100 cases in each by random digits table. Observation group was treated with four intramuscular injections of 6 mg dexamethasone in the 24 hours to 7 days before delivery, and control group was treated with 0.9% sodium chloride injection with the same method. The clinical data and the incidence of the wet lung syndrome of the newborn were collected. Results The incidence of the wet lung syndrome of the newborn was 1%（1/100） in observation group and 9%（9/100） in control group,and the incidence of the severity of the wet lung syndrome of the newborn was 1%（1/100） in observation group and 2% （2/100） in control group. There were no complication in observation group and 1 case in control group. The incidence and the severity of the wet lung syndrome of the newborn in observation group were less than that in control group significantly （P = 0.009,0.049）. Conclusion Prenatal dexamethasone treatment can reduce the incidence of the wet lung syndrome of the newborn and decrease the incidence of the severity and complication of elective caesarean section at term.

关 键 词：肺水肿 婴儿 新生 地塞米松 剖宫产 

分 类 号：R722.1[医药卫生—儿科]