大骨节病临床症状、体征的分布规律  

THE DISTRIBUTIVE CHARACTERISTICS OF CLINICAL SYMPTOMS AND SIGNS IN KASHIN - BECK DISEASE

作　　者：龚芳[1] 李强[2] 郭雄[3] 

机构地区：[1]西安公路交通大学数学教研室 [2]西安医科大学统计与数学教研室 [3]西安医科大学地方性骨病研究所

出　　处：《中国地方病防治》1999年第5期266-268,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的 本文分析了大骨节病临床症状的检出率及分布规律,探讨和评价诊断本病意义和关节损害的特点。方法 选择大骨节病横断面流行病学调查中2913例非病区与病区健康、大骨节病病例的34个临床症状体征进行病例对照分析。结果①掌指骨X线异常病变是早期患者的主要表现,并仍存在于大骨节病不同程度的病例中;②下蹲障碍和指粗是大骨节病Ⅰ度、Ⅱ度、Ⅲ度病例与早期患者的显著不同体征;③关节损害的特点是从四肢到脊柱,并呈上、下肢对称性损害。结论 大骨节病临床症状体征的检出率与病情的严重程度有关,对进一步评价临床诊断指标有一定的重要意义。The distributive characteristics of clinical symptoms and signs in Kashin - Beck disease (KBD) and non - KBD were investigated in this paper in order to understand the feature of damaged joints in KBD and to evaluate the diagnostic significance for this disease. Methods: 37 clinical symptoms and signs of 2 913 cases from KBD areas and non - KBD areas were analyzed in the cross section epidemiological survey of KBD. Results: ① The abnormal pathologic changes of metacarpal -phalanges on X - ray film of hands were main manifestations, and still appeared in the different degree cases with KBD. ② The limited squatting enlargement of finger joints in KBD patients from the first degree to the third degree significantly different from the early stage of this disease.③The characteristics of joint damage were developed from limbs to spine with symmetric changes between the upper lirnbs and the low limbs. Conclusion: The abnormal rate, of clinical symptoms and signs in KBD were related to the serious degree of the disease. It is important to evaluate the clinical diagnostic indexes for KBD.

关 键 词：大骨节病 频率分布 诊断 临床症状 

分 类 号：R684.1[医药卫生—骨科学]