Treatment of primary hepatic carcinoma by transcatheter arterial perfusion of batroxobin combined with TACE:a preliminary clinical study  

巴曲酶灌注联合肝动脉化疗栓塞治疗原发性肝癌的临床初步研究(英文)

作　　者：Tianjun Gao Mingwu Lou Hui Wang Yi Fan Yunxia Shen Jiyin Ruan Hongguang Zhang 

机构地区：[1]Department of Interventional Radiology, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, China [2]Department of Intervention, Tumour Hospital of Jilin Province, Changchun 130012, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2011年第2期96-99,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by a grant from the Sciences and Technology Foundation of Guangdong Province (No. 73128)

摘　　要：Objective:The aim of the study was to explore the therapeutic efficacy and safety of batroxobin in patients with primary hepatic carcinoma(PHC) and the advantages of transcatheter arterial perfusion of batroxobin combined with transcatheter arterial chemoembolization(TACE).Methods:Forty patients with PHC were randomized into experimental group(transcatheter arterial perfusion of batroxobin combined with TACE treatment,20 patients) and control group(TACE alone group,20 patients).The patients were followed up and the data were recorded,compared and analyzed.Results:(1) Compared with the control group,the FIB level in the experimental group was significantly decreased at the first month after treatment(P < 0.05).(2) The baseline of the tumor was shortened in both groups after the treatment.There was a significant difference between the two groups at different time intervals(P < 0.05).(3) After the treatment,there was a significant difference of progression-free survival(PFS) levels between the two groups(t =2.877,P < 0.05).(4) The incidence of metastasis were 5.0%(1/20) in both groups at 6 months after treatment,and that after one year was 10.0%(2/20) in the experimental group and 25.0%(5/20) in the control group.However,the difference was not significant(χ2 = 0.693,P > 0.05).Conclusion:Batroxobin can rapidly and effectively decrease the FIB level of the PHC cases.Therefore it may be used as an effective and safe adjuvant drug for the treatment of primary hepatic carcinomas.Transcatheter arterial perfusion of batroxobin combined with TACE therapy has advantages in comparison with TACE alone therapy.It could be taken as a new therapeutic regimen in the PHC treatment.

关 键 词：BATROXOBIN liver neoplasms FIBRINOGEN therapy transcatheter arterial chemoembolization（TACE） 

分 类 号：S858.285.3[农业科学—临床兽医学] S865.28[农业科学—兽医学]