路优泰联合激素与单纯激素替代治疗围绝经期妇女抑郁症疗效的比较  

Comparison of the clinical effects of Neurostan combined with hormone replacement therapy and single hormone replacement therapy in treatment of perimenopausal women with depression

作　　者：李轶琳[1] 崔满华[2] 高双[1] 赵丽华[1] 

机构地区：[1]大庆油田总医院妇产科,黑龙江大庆163001 [2]吉林大学第二医院妇产科

出　　处：《中国妇幼保健》2011年第5期667-669,共3页Maternal and Child Health Care of China

基　　金：2010年度黑龙江省卫生厅科技计划项目(2010-384)

摘　　要：目的:观察圣约翰草提取物(路优泰)与激素替代治疗(HRT)围绝经期抑郁症的疗效。方法:将围绝经期妇女合并抑郁症诊断的患者60例,随机分成2组,每组30例。路优泰联合HRT组:每21天为一个治疗周期,应用克龄蒙(其组分为:11片白片,每片含戊酸雌二醇2 mg;10片呈浅红色片,每片含戊酸雌二醇2 mg+醋酸环丙孕酮1 mg),路优泰900 mg/d。单纯应用HRT组:应用克龄蒙组(其组分为:11片白片,每片含戊酸雌二醇2 mg;10片浅呈红色片,每片含戊酸雌二醇2 mg+醋酸环丙孕酮1 mg)。两组均治疗12周。于治疗2、3、4、6、8、12周各随访1次,应用汉密尔顿抑郁量表(Ham ilton depression score,HAMD)评价抑郁症程度,应用Kupperm an绝经指数(KM I)评价围绝经期症状。结果:治疗前HAMD评分,联合HRT组与单纯HRT组分别为(24±6)分和(25±6)分,两组比较,差异无统计学意义(P>0.05)。治疗第3周,路优泰联合HRT组为(14±6)分,与治疗前比较,差异有统计学意义(P<0.05);单纯HRT组为(18±7)分,与治疗前比较差异有统计学意义(P<0.05);但两组治疗后比较,差异无统计学意义。治疗3周后,两组HAMD评分比较,差异有统计学意义(P<0.05)。至治疗第8周HAMD评分,路优泰联合HRT组与单纯HRT组分别为(3±1)分和(9±6)分,两者比较差异有统计学意义(P<0.001)。治疗前KM I评分,路优泰联合HRT组与单纯HRT组分别为(32±8)分和(31±6)分,两者比较,差异无统计学意义(P>0.05)。治疗7周后,两组KM I评分分别为(9±5)分和(12±6)分,两组比较差异有统计学意义(P<0.05)。治疗结束后,路优泰联合HRT组与单纯HRT组的抑郁症治愈率分别为89%和45%,两组比较差异有统计学意义(P<0.001)。结论:路优泰联合HRT治疗围绝经期抑郁症的疗效,明显优于单纯应用HRT。Objective：To observe the clinical efficacy of the extract of Saint John＇s Wort（Neurostan） combined with hormone replacement therapy（HRT） in treatment of perimenopausal depression.Methods：60 perimenopausal women with depression were divided into two groups randomly,30 women in each group;Neurostan combined with HRT group： every treatment cycle had 21 days,the women were treated with Climen and Neurostan（900 mg/d）;single HRT group： the women were treated with Climen;the women in the two groups were treated for 12 weeks;and they were followed up at 2,3,4,6,8 and 12 weeks after treatment,Hamilton Depression score（HAMD） was used to assess the degree of depression,Kupperman menopause index（KMI） was used to assess the perimenopausal symptoms.Results：The HAMD scores before treatment in Neurostan combined with HRT group and single HRT group were（24±6） and（25±6）,respectively,there was no significant difference between the two groups（P0.05）;at 3 weeks after treatment,the HAMD score in Neurostan combined with HRT group was（14±6）,there was significant difference before and after treatment（P0.05）;the HAMD score in single HRT group was（18±7）,there was significant difference before and after treatment（P0.05）;but there was no significant difference in HAMD score after treatment between the two groups;there was significant difference in HAMD score at 3 weeks after treatment between the two groups（P0.05）;at 8 weeks after treatment,the HAMD scores in Neurostan combined with HRT group and single HRT group were（3±1） and（9±6）,respectively,there was significant difference between the two groups（P0.001）;the KMI before treatment in Neurostan combined with HRT group and single HRT group were（9±5） and（12±6）,respectively,there was significant difference between the two groups（P0.05）;after treatment,the cure rates of depression in Neurostan combined with HRT group and single HRT group were 89% and 45%,respectively,there was significant difference b

关 键 词：抑郁症 围绝经期综合征 路优泰 激素替代治疗 

分 类 号：R458.7[医药卫生—治疗学]