孕妇血管内皮生长因子及受体-1水平变化与妊娠结局的关系  

Changes of vascular endothelial growth factor and its soluble receptor-1 levels and the relationship with pregnancy outcomes of pregnant women

作　　者：耿淑平[1] 苏玲娣[1] 单峰[1] 

机构地区：[1]南通大学第二附属医院妇产科,江苏南通226001

出　　处：《中国妇幼保健》2011年第5期730-732,共3页Maternal and Child Health Care of China

基　　金：南通市科技局资助项目〔No.S2007021〕

摘　　要：目的：探讨血管内皮生长因子（VEGF）及受体-1（sFlt-1）在正常妊娠及子痫前期孕妇血清中水平与妊娠结局的关系。方法：采用酶联免疫吸附试验（ELISA）法测定30例子痫前期患者（其中轻度11例,重度19例）的外周血（静脉血）VEGF、sFlt-1,并与30例正常孕妇作对照。结果：子痫前期孕妇血清中VEGF水平比正常对照组低,sFlt-1水平比正常对照组高（P〈0.01）,重度子痫前期孕妇血清中VEGF水平比轻度低,sFit-1水平比轻度高（P〈0.05）。比较子痫前期孕妇与正常孕妇的妊娠结局,两者在分娩孕周、宫高、腹围、胎儿双顶径、新生儿体重1 min Apgar评分、羊水Ⅱ-Ⅲ污染度、胎盘重量均存在差异。结论：子痫前期患者血清中VEGF、silt-1水平的改变会引起内皮细胞激活和损伤,从而导致高血压、蛋白尿等临床症状,并对围产儿的结局有一定影响。Objective：To explore the serum levels of vascular endothelial growth factor（VEGF） and its soluble receptor-1（sFIt-1） in normal pregnant women and pregnant women with preeclampsia and the relationship with pregnancy outcomes.Methods：Enzyme-linked immunosorbent assay（ELISA） was used to detect the expression levels of EGF and sFIt-1 in peripheral blood of 30 patients with preeclampsia（11 cases with mild preeclampsia and 19 cases with severe preeclampsia）（preeclampsia group） and 30 normal pregnant women（control group）,then the results were compared.Results：The serum level of VEGF in preeclampsia group was significantly lower than that in control group,the serum level of sFIt-1 in preeclampsia group was significantly higher than that in control group（P0.01）;the serum level of VEGF in severe preeclampsia group was significantly lower than that in mild preeclampsia group,the serum level of sFIt-1 in severe preeclampsia group was significantly higher than that in mild preeclampsia group（P0.05）;there was significant difference in pregnancy outcomes（including delivery pregnancy week,fundal height,abdominal circumference,fetal biparietal diameter,1 minute Apgar score of neonatal body weight,amniotic fluid II-III pollution and placental weight） between preeclampsia group and control group.Conclusion：The changes of VEGF and sFIt-1 in serum of patients with preeclampsia may induce endothelial cell activation and injury,lead to hypertension,proteinuria and other clinical symptoms,which affect the perinatal outcomes to some extent.

关 键 词：血管内皮生长因子 可溶性受体-1 子痫前期 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]