不同灸量麦粒灸调节血脂效应的比较研究  

Comparative Study on the Effect of Moxibustion with Wheat Grain Sized Cones at Different Dosages for Regulating Blood Fat

作　　者：张细柳[1] 王士超[1] 王耀帅[1] 王玲玲[1] 徐斌[1] 

机构地区：[1]南京中医药大学针药结合实验室

出　　处：《中医杂志》2011年第5期413-415,共3页Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划("973计划")资助项目(2009CB522905)

摘　　要：目的观察不同灸量麦粒灸对急性高血脂状态大鼠的调节效应差异及量效特征。方法采用腹腔注射蛋黄乳液方法制备急性高脂血症大鼠模型。将72只SD大鼠随机分为正常空白组、模型对照组、药物治疗组、麦粒灸3壮组、麦粒灸6壮组、麦粒灸9壮组各12只,各艾灸治疗组分别按每穴每日3壮、6壮、9壮的灸量施灸于神阙、后三里,药物治疗组用洛伐他汀混悬液以每日10mg/kg剂量灌胃给药,治疗3日。治疗结束后测定各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果模型对照组大鼠血清TC、TG、LDL-C均升高,HDL-C降低,与正常空白组比较差异有统计学意义(P<0.01)。与模型对照组比较,药物治疗组及不同灸量组均可降低模型大鼠血清TC、TG、LDL-C,升高HDL-C,差异有统计学意义(P<0.05或P<0.01)。其中麦粒灸6壮组、9壮组降低TG方面优于药物对照组和麦粒灸3壮组(P<0.01);麦粒灸3壮组与药物对照组升高HDL-C方面优于麦粒灸6壮组(P<0.05或P<0.05)。结论不同灸量麦粒灸对急性高血脂状态大鼠均具有普遍性调节效应,其中降低TG方面6壮和9壮的效应最佳,升高HDL-C方面3壮和药物的效应更优。Objective To observe the difference and dose-effect relationship of moxibustion with wheat grain sized cones at different dosages for regulating the blood fat in acute hyperlipemia rats. Methods The acute hyperlipemia rat models were made by intraperitoneal injection of yolk emulsion. Totally 72 SD rats were randomized into 6 groups：normal control group,hyperlipemia model group,medicinal treatment group,wheat grain sized 3-Cone moxibustion group,wheat grain sized 6-Cone moxibustion group,and wheat grain sized 9-Cone moxibustion group,12 rats in each group. The moxibustion groups were treated respectively with 3 cones,6 cones,and 9 cones each point per day at Shenque （CV8） and Housanli （ST36）. The medicinal treatment group was treated with Lovastatin suspension for gastric injection at the dosage of 10 mg/（kg·d）. The treatment lasted for 3 days. After treatment,we tested the serum total cholesterol （TC）,triglyceride （TG）,low density lipoprotein C （LDL-C）,and high density lipoprotein C （HDL-C）. Results In the hyperlipemia model group,the serum TC,TG,and LDL-C were all increased,while the HDL-C was decreased. Compared with the normal control group,there was statistical difference（P0.01）. Compared with the hyperlipemia model group,the medicinal treatment group and the moxibustion groups could make the TC,TG,and LDL-C decreased and HDL-C increased with statistical difference （P0.05 or P0.01）. Of the moxibustion groups,the 6-Cone and 9-Cone groups were superior to the medicinal treatment group and 3-Cone moxibustion group in decreasing TG （P0.01）. The 3-Cone moxibustion group and medicinal treatment group were better than the 6-Cone moxibustion group in increasing HDL-C （P0.05 or P0.01）. Conclusion The moxibustion with wheat grain sized cones at different dosages is all effective in regulating the blood fat in acute hyperlipemia rats. For decreasing TG,the effect of 6-Cone and 9-Cone is the best,and for increasing HDL-C,the effect of 3-Cone and the medicinal treatment is b

关 键 词：麦粒灸 高脂血症 灸量 灸法 

分 类 号：R245[医药卫生—针灸推拿学]