t-复合多肽1基因在原发性肾病综合征患者外周血单个核细胞中的表达  

Expression of TCP-1 in patients with primary nephrotic syndrome

作　　者：盛梅[1] 曹灵[1] 李霞斌[2] 李瑶[2] 孙兴旺[2] 

机构地区：[1]泸州医学院附属医院肾内科,646000 [2]泸州医学院附属医院病理科,646000

出　　处：《实用医学杂志》2011年第5期778-780,共3页The Journal of Practical Medicine

基　　金：四川省教育厅重点项目(编号:2006A049);泸州市科技局项目[编号:2007(64)-2]

摘　　要：目的:初步探讨t-复合多肽1(TCP-1)基因在原发性肾病综合征(PNS)患者外周血单个核细胞(PBMC)中的表达及临床意义。方法:收集体检20例正常人(A组)和30例PNS患者(B+C组,其中B组为初发PNS患者,未用激素;C组为复诊PNS患者,使用激素2～3个月。各15例)的新鲜外周血液。用RT-PCR检测其外周血PBMC中TCP-1基因的表达。结果:A组分别与B+C组、B组、C组相比,TCP-1基因的表达差异均有显著性(P<0.01);B组与C组中的表达差异无显著性(P>0.05)。结论:TCP-1可能参与了PNS的发生发展过程。Objective To explore the expression of t-complex polypeptide 1（TCP-1）in patients with primary nephrotic syndrome（PNS）and its clinical significance.Methods Fresh blood samples were collected from 20 healthy adults（group A）,and 30 PNS patients（group B ＋ C）,15 of whom received glucocorticoids for 2 to 3 months（group C）or no glucocorticoids（group B）.The expressions of TCP-1 in peripheral blood mononuclear cells were detected by RT-PCT.Results TCP-1 expression differed significantly between group A and group B ＋ C（P 0.01）,group B,or group C（P 0.01）;however,there was no significant difference between group B and group C.Conclusions TCP-1 may be involved in the pathogenesis and development of primary nephrotic syndrome.

关 键 词：肾病综合征 TCP-1 PBMC RT-PCR 糖皮质激素 

分 类 号：R692.3[医药卫生—泌尿科学]