美司钠联合水化、利尿、碱化预防造血干细胞移植中出血性膀胱炎的效果与护理  

Effect and nursing of mesna combined with hydration, alkalizing and diuresis to prevent hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation

作　　者：王翠林[1] 胡文娟 吴燕君[1] 

机构地区：[1]广州市第十二人民医院血液科,510620 [2]广州市越秀区正骨医院骨科,510620

出　　处：《中华现代护理杂志》2011年第5期536-538,共3页Chinese Journal of Modern Nursing

摘　　要：目的 探讨美司钠联合水化、强迫利尿、碱化对造血干细胞移植（HSCT）预处理过程中应用环磷酰胺时引起出血性膀胱炎（HC）的预防效果和护理方法.方法 本组32例接受HSCT的患者,其中2例采用TBI/CY预处理方案,30例采用经典的BU/CY预处理方案.所有患者均采用美司钠联合水化、强迫利尿、碱化预防HC.结果 仅1例患者移植后6个月出现迟发型Ⅱ度HC,其余患者均未出现HC.结论 美司钠联合水化、强迫利尿、碱化预防HC是有效的、安全的,值得临床推广应用.Objective To observe the effect of mesna combined with hydration, alkalizing and diuresis for preventing hemorrhagic cystitis caused by cyclophosphamide after allogenic hematopoietic stem cell transplantation. Methods Thirty-two patients after HSCT were enrolled into this research, two of whom received the conditioning regimen of TBI/CY, while the rest received the classic conditioning regimen. All patients were treated with mesna combined with hydration, forced diuresis and alkalizing to prevent HC. Results In all the treated patients but one presented with late-onset type HC （Ⅱ）. Conclusions Mesna combined with hydration,forced diuresis and alkalizing could effectively and safely prevent HC.

关 键 词：出血性膀胱炎 造血干细胞移植 美司钠 水化 利尿 碱化 护理 

分 类 号：R473.5[医药卫生—护理学]