贻贝多糖胶囊毒理学安全性研究  

A toxicological security study of Mytihus Edulis Linnaeus Polysaccharides Capsule

作　　者：吴涓[1] 孙倩[2] 储智勇[2] 祝德秋[1] 汪家春[2] 栾洁[2] 张术[2] 

机构地区：[1]同济大学附属同济医院药剂科,上海200065 [2]海军医学研究所,上海200433

出　　处：《中国卫生检验杂志》2011年第1期97-100,共4页Chinese Journal of Health Laboratory Technology

基　　金：上海鲲禹科贸有限公司资助

摘　　要：目的:对贻贝多糖胶囊的食用安全性进行毒理学评价。方法:采用急性毒性实验、遗传毒性实验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)和30 d喂养试验进行评价。结果:小鼠经口MTD均大于15.0 g/kg,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性。30 d喂养试验未见大鼠的生长发育、血液学、生化、脏器比及组织病理学有异常变化。结论:贻贝多糖胶囊急性毒性分级属无毒级,无遗传毒性,最大无损害作用剂量大于1.6 g/kg,相当于人体推荐摄入量的120倍。在本实验剂量范围内,贻贝多糖胶囊属安全性保健食品。Objective：To estimate the toxicological characterization of mytihus edulis linnaeus polysaccharides（MELP） capsule.Motheds： Acute toxicity test,genetic toxicity test（Ames test,micronucleus test of born marrow in mice,sperm shape abnormality test in mice） and thirty-day feeding test in rats were used in this study according to the procedures for toxicological assessment of food.Results： The oral MTD in mice was more than 15.0 g/kg,the results of Ames test,micronucleus test of born marrow in mice and sperm shape abnormality in mice were negative.The thirty-day feeding test in rats demonstrated that it had no obvious toxic effects on growth and development,routine blood,biochemical index,VSI and histopathologica changes.Conclusion： MELP capsule test results showed non-toxic and non-genetic toxicity in acute toxicity test.The lagest dose of this sample for no obvious adverse effects was 1.6 g/kg,which is equivalent to 120 times of the recommended amount for human body.Within the scope of this test dose,MELP capsule is a kind of health food products.

关 键 词：贻贝多糖胶囊 毒理学 安全性 

分 类 号：R965.3[医药卫生—药理学]