D型人格急性冠脉综合征患者血清IL-6、IL-18水平研究  

A study of serum interleukin 6 and interleukin 18 in acute coronary syndrom patients with type D personality

作　　者：宁淑娥[1] 曲鹏[1] 魏刚 郑美丽[1] 隋政[1] 宗大飞[1] 张兴[1] 

机构地区：[1]大连医科大学第二临床学院心内科,大连116013 [2]大连市甘井子区政府信访局

出　　处：《中华行为医学与脑科学杂志》2011年第2期122-124,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金资助项目（30670836）

摘　　要：目的探讨D型人格急性冠脉综合征（ACS）患者血清白细胞介素-6（IL-6）和白细胞介素-18（IL-18）]水平，为阐明D型人格影响ACS预后的生理机制提供依据。方法使用D型人格量表（DS14）评定214例ACS患者人格基础。依据DS14得分，DS14分量表消极情感（NA）和社会禁止（SI）同时都≥10分的ACS患者入D型人格ACS组（D型组）（50例），余下的164例为非D型人格ACS组（非D型组）。采用酶联免疫吸附法检测214例ACS患者急性期和恢复期血清IL-6、IL-18水平。比较两组IL-6、IL-18血清水平差异。结果D型人格ACS患者检出率为23．36％。D型组急性期及恢复期血清IL-6[分别为（2．340±0．081）OD值，（2．016±0．023）OD值]、血清IL-18[分别为（1．460±0．070）OD值，（1．313±0．012）OD值]，均高于非D型组血清IL-6[分别为（2．178±0．180）OD值，（1．849±0．159）OD值]、血清IL-18[分别为（1．387±0．091）OD值，（1．196±0．132）OD值]，差异具有显著性妒〈0．01]。结论D型人格ACS患者检出率与国外相当；D型人格ACS患者血清中持续高水平的促炎细胞因子（IL-6、IL-18）与他们患急性冠脉综合征后易发生不良事件密切相关，可能是影响预后的一个生物学机制。Objective To explore what kind of role serum interleukin 6 （IL-6）and interleukin 18 （IL- 18）play in the relationship between type D personality and acute coronary syndrom （ACS）prognosis. Meth- otis Serum levels of IL-6,IL-18 in all 214 ACS patients were measured with ELISA. According to the scores of type D personality scale（DS14）,the subjects were divided into the group with type D personality （50 cases）and the one without type D personality （ 164 cases）. The serum IL-6 and IL-18 level between the two groups were detected and analyzed. Results There were 23.36% ACS patients with type D personality. The sentm IL-6, IL-18 levels of the group with type D in ACS acute stage and ACS recovery stage were （2. 340 ± 0.081 ） OD, （ 2. 016 ±0.023 ） OD and （ 1. 460 ± 0. 070 ） OD, （ 1.313 ±0.012 ） OD respectively, significantly higher than those of the group without type D （2. 178 ± 0.180） OD, （ 1. 849 ± 0. 159 ）OD and （ 1. 387± 0. 091 ）OD, （ 1. 196 ± 0.132 ） OD respectively（P〈0.01）. Conclusion At home and abroad ,there are similar amount of ACS patients with type D personality. The high serum IL-6 and IL-18 levels may play an important role in pathogenesis of relationship between type D personality and ACS poor prognosis.

关 键 词：D型人格 急性冠脉综合征 预后 白细胞介素-6 白细胞介素-18 

分 类 号：R541.4[医药卫生—心血管疾病]