老年冠心病患者血清胆红素和超敏C反应蛋白水平的变化分析  

Analysis of serum bilirubin and high-sensitivity C-reactive protein in elderly patients with coronary artery disease

作　　者：王瑞涛[1] 孟松艳[1] 杨奕[1] 李颖[1] 

机构地区：[1]哈尔滨医科大学附属第二医院老年病科,黑龙江哈尔滨150086

出　　处：《现代医学》2011年第1期32-35,共4页Modern Medical Journal

摘　　要：目的:分析血清胆红素和超敏C反应蛋白(hs-CRP)水平与冠心病的关系及规律用药的重要性。方法:对150例经冠状动脉造影明确诊断为冠心病的患者(治疗组)和150例无冠心病的老年人(对照组)测定血清总胆红素(TB IL)、直接胆红素(DB IL)、间接胆红素(IDB IL)水平以及hs-CRP水平;治疗组患者规律用药12个月后复查上述指标。结果:治疗组血清TB IL和IDB IL水平明显低于对照组(P<0.05),而hs-CRP水平明显高于对照组(P<0.05);12个月后,治疗组血清TB IL和IDB IL水平升高,hs-CRP水平下降,与自身比较有显著性差异(P<0.05)。结论:血清胆红素水平升高可能在冠心病发病中具有一定的保护作用;血清胆红素和hs-CRP水平均可作为病情监测的指标;规律用药对老年冠心病患者具有重要意义。Objective：To evaluate clinical value of the serum bilirubin and serum high-sensitivity C-reactive protein（hs-CRP） in patients with coronary artery disease and stress the importance of maintenance of regular medication.Methods： 150 cases with coronary artery disease（diagnosed by angiography） were collected and 150 cases without coronary artery disease served as controls.The levels of serum bilirubin and Hs-CRP were measured.The patients with coronary artery disease received regular medication for 12 months and the levels of serum bilirubin and Hs-CRP were re-tested.Results： In the treatment group,TBIL and IDBIL levels decreased（P0.05）,hs-CRP level significantly elevated compared with those in control group（P0.05）.Twelve months later,TBIL and IDBIL levels of the patients with coronary artery disease increased（P0.05）,hs-CRP level was decreased significantly compared with themselves（P0.05）.Conclusion： The elevated TBIL and IDBIL play a protective role in the mechanism of coronary artery disease.Serum bilirubin and Hs-CRP level in patients with coronary artery disease may serve as therapeutic indicators.It is important for elderly patients to maintain a regular medication.

关 键 词：血清胆红素 超敏C反应蛋白 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]