阿托伐他汀钙片治疗高脂血症198例疗效分析  

Clinical observation on atorvastatin among 198 patients with hyperlipidemia

作　　者：李勃[1] 肖引[1] 闫美娟[1] 刘凯[1] 陈芳[1] 

机构地区：[1]武警陕西总队医院药剂科,陕西西安710054

出　　处：《现代医学》2011年第1期57-59,共3页Modern Medical Journal

摘　　要：目的:探讨阿托伐他汀钙片10 mg.d-1治疗高脂血症的疗效。方法:对198例确诊为高脂血症的患者予阿托伐他汀钙片10 mg 1次.d-1,连服8周,观察用药前及服药后4、8周血脂水平的变化,同时观察患者有无不良反应。结果:经过8周治疗后,患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)都有显著降低(P<0.001或P<0.01),高密度脂蛋白胆固醇(HDL-C)有明显升高(P<0.01);治疗过程中3例患者胃肠道不适,对症治疗后症状缓解,其余患者未发现明显不良反应。结论:阿托伐他汀钙片治疗高脂血症疗效确切,不良反应少。Objective：To investigate the efficacy of atorvastatin（10 mg·d-1）in the treatment of hyperlipidemia.Methods： 198 patients with hyperlipidemia were treated with atorvastatin at a dose of 10 mg daily for eight weeks.The change of blood lipid level was observed after 4 and 8 week,including the side effect.Results： After 8 weeks of treatment,TC,LDL-C and TG in atorvastatin patients were significantly decreased（P0.001,P0.01）;HDL-C increased obviously（P0.01）.In the treating course,no other adverse reactions occurred except 3 cases of gastrointestinal tract discomfort.Conclusion： Atorvastatin is a safe and effective drug for hyperlipidemia with little adverse reactions.

关 键 词：阿托伐他汀 高脂血症 治疗 

分 类 号：R589.2[医药卫生—内分泌] R972.6[医药卫生—内科学]