Enantiomeric Separation of Antidepressant Trimipramine by Capillary Electrophoresis Combined with Electrochemiluminescence Detection in Aqueous-organic Media  

作　　者：YU Cai-xia YUAN Bai-qing YOU Tian-yan 

机构地区：[1]State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, P. R. China [2]Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China

出　　处：《Chemical Research in Chinese Universities》2011年第1期34-37,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No20875085);the Fund of Chinese Academy of Sciences(NoKJCX2-YW-H11)

摘　　要：The antidepressant trimipramine（Tri） enantiomers were successfully separated by capillary electrophoresis（CE） coupled with electrochemiluminescence（ECL） detection in aqueous-organic media. A dual cyclodextrin（CD） system combining β-CD and hydroxypropyl-β-cyclodextrin（HP-β-CD） was used as chiral selector. Acetonitrile（ACN） was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.The antidepressant trimipramine（Tri） enantiomers were successfully separated by capillary electrophoresis（CE） coupled with electrochemiluminescence（ECL） detection in aqueous-organic media. A dual cyclodextrin（CD） system combining β-CD and hydroxypropyl-β-cyclodextrin（HP-β-CD） was used as chiral selector. Acetonitrile（ACN） was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.

关 键 词：Capillary electrophoresis ELECTROCHEMILUMINESCENCE Trimipramine ENANTIOSEPARATION Organic additive 

分 类 号：O614.812[理学—无机化学] O657.8[理学—化学]