内外源性β-葡萄糖醛酸酶与原发性胆总管结石的关系  

The relation between the activities of endogenous and exogenous β-glucuronidase and primary common duct stones

作　　者：陶应田 孟翔凌[2] 徐阿曼[2] 文刚 涂从银 黄赵刚[3] 夏泉[3] 

机构地区：[1]安徽医科大学第三附属医院普外科,合肥230061 [2]安徽医科大学第一附属医院普外科,合肥230061 [3]安徽医科大学第一附属医院药剂科,合肥230061

出　　处：《中国医师进修杂志》2011年第5期18-20,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨内外源性β葡萄糖醛酸酶（β—G）与原发性胆总管结石的关系。方法应用改良Fishman法检测35例原发性胆总管结石患者（试验组）和11例胆囊息肉患者（对照组）胆总管内胆汁中内外源性β-G活性。结果试验组和对照组手术当天胆汁中内源性β-G活性分别为（7859．1±738．5）、（2174．9±348．4）U/L（P〈0．01）；外源性β—G活性分别为（6786．1±544．3）、（1504．7±655．7）U/L（P〈0．01）；试验组中13例急性患者手术当天与术后第7天胆汁中外源性β-G活性分别为（8935．7±845．9）、（2176．1±956．7）U／L（P〈0．05）；22例慢性患者分别为（5137．2±540．7）、（1838．8±733．3）U/L（P〈0．05）；急性患者手术当天胆汁中外源性β-G活性明显高于慢性患者（P〈0．05）。结论内、外源性8．G参与原发性胆总管结石的形成。Objective To explore the role of endogenous and exogenous β-glucuronidase （β -G） in the development of primary common duct stones. Method Using modified Fishman method to test the activities of the endogenous and exogenous β-G in 35 patients with primary common duct stones（experimental group） and 11 patients with cystic polypus （control group） respectively. Results The activities of endogenous β-G in the bile of experimental group and control group were （7859.1 ± 738.5 ）, （2174.9 ± 348.4 ） U/L（P 〈 0.01 ）.While the activities of exogenous β-G in experimental group and control group were （6786.1 ± 544.3）, （1504.7±655.7） U/L （P 〈0.01）. In experimental group, there were significant statistical differences in the activities of the exogenous β -G in the sample obtained on the day of operation and 7 days after operation from 13 cases with the acute inflammation [ （8935.7 ± 845.9）, （2176.1 ± 956.7） U/L] and from 22 cases with the chronic inflammation [ （5137.2 ± 540.7）, （1838.8 ± 733.3） U/L],and there were significant higher in the activities of the exogenous β-G in the sample obtained on the day of operation from the acute inflammation compared to those from the chronic inflammation （P 〈 0.05 ）. Conclusions There is obvious correlation between either endogenous or exogenous β-G with primary common duet stones. And the endogenous β-G might be one of the fundamental cause in the development of primary common duet stones.

关 键 词：葡糖醛酸糖苷酶 胆总管结石 

分 类 号：R657.42[医药卫生—外科学]