大黄对急性胰腺炎治疗作用的实验研究  

Experimental Studies of Therapeutic Effect of Rheum officinale on Acute Pancreatitis

作　　者：杨昌永[1] 申理[1] 谢珍国[1] 蒋星[1,2] 梁楠[1] 陈重华[1] 

机构地区：[1]四川大学华西药学院药理教研室,四川成都610041 [2]国家成都中药安全性评价中心,四川成都610041

出　　处：《中药材》2011年第1期84-88,共5页Journal of Chinese Medicinal Materials

摘　　要：目的:研究大黄对急性胰腺炎的治疗作用。方法:应用逆行胆管注射3%牛黄胆酸钠诱导大鼠急性胰腺炎,分别于造模后6、12、24 h观察大鼠的死亡率,胰腺系数,血清中淀粉酶(AMY)、超氧化物歧化酶(SOD)、TNF-α和IL-1β含量,并对胰腺进行病理学检测。结果:与模型组比较,各时间点给药组的死亡率、胰腺质量、血清TNF-α和IL-1β含量均显著降低(P<0.05),血清SOD活性显著升高(P<0.01);给药组AMY含量于造模后6 h时显著低于模型组(P<0.01)1,2 h时显著高于模型组(P<0.01)2,4 h时两者未见统计学差异(P>0.05);各给药组病理得分与模型组相比均显著降低,但得分增高的趋势类似。结论:大黄对模型动物的胰腺病变有保护作用,但不能逆转其变化趋势。Objective ： To investigate the therapeutic effect of Rheum officinale on acute pancreatitis. Methods ： Buffered sodium taurocholate（3% m/V） was injected into the pancreatico-biliary duct to induce acute pancreatitis. Death rate,coefficient of pancreas, serum amylyse（AMY） ,hemocuprein（SOD） ,TNF-α and IL-1β level were examined at 6,12 and 24 hours after operations. Pathology analysis were also obtained. Results：Compared with corresponding pancreatitis groups, death rate, coefficient of pancreas, serum TNF-α and IL-1β level of drug groups decreased remarkably（ P 〈 0. 05 ）, while serum SOD level significantly increased（ P 〈 0. 01 ）. Serum AMY level of drug groups increased at 6 h（P 〈 0. 01 ）, decreased at 12 h（ P 〈 0. 01 ）and had no statistics disparity at 24 h（P 〉 0. 05 ） compared with respective pancreatitis group. Although score points of all drug groups were lower than corresponding pancreatitis groups, the growth tendency of both were similar. Conclusion ： Rheum officinale Baill has the effect of prevention to pancreas pathological changes in the animal pattern, but not able to reverse the tendency.

关 键 词：大黄 急性胰腺炎 施密特标准 TNF-Α IL-1Β 

分 类 号：R285.5[医药卫生—中药学]