Feasibility Study of Aluminum Hydroxide Sol as Adjuvant to Prepare Stable Vaccine Using Newcastle Disease Virus as a Model  

作　　者：SONG Meirong LI Xinsheng GAO Wenming FANG Shaoming CUI Baoan 

机构地区：[1]College of Animal Science and Veterinary Medicine,Henan Agricultural University, Zhengzhou 450002, Henan, China [2]Henan Provincial Key Laboratory of Surface and InterfaceScience, Zhengzhou University of Light Industry, Zhengzhou450002, Henan, China

出　　处：《Wuhan University Journal of Natural Sciences》2011年第1期88-92,共5页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Science and Technology Supporting Program in the Eleventh Five-Year Plan of China (2006BAD06A08)

摘　　要：Aluminum hydroxide sol （consisting of aluminum hydroxide nano-particles） prepared by a hydrothermal method was used as nano-aluminum adjuvant adsorbed the inactived Newcastle disease virus （NDV）. The zeta potential of aluminum hydroxide colloidal particles,the inactivated NDV and the nano-aluminum adjuvant NDV are ＋48.16 mV,？13.8 mV and ＋39.97 mV,respec-tively. The nano-aluminum adjuvant vaccine was transparent and stable without precipitate,whereas the conventional aluminum ad-juvant vaccine was turbid and a white precipitate was visible soon. The hemagglutination inhibition （HI） titers of the nano-aluminum adjuvant group were generally higher than those of the conventional aluminum group except the titer on day 29. The results show that the nano-aluminum adjuvant has better stability and higher levels of antibodies for a longer time than the conventional aluminum adjuvant.Aluminum hydroxide sol （consisting of aluminum hydroxide nano-particles） prepared by a hydrothermal method was used as nano-aluminum adjuvant adsorbed the inactived Newcastle disease virus （NDV）. The zeta potential of aluminum hydroxide colloidal particles,the inactivated NDV and the nano-aluminum adjuvant NDV are ＋48.16 mV,？13.8 mV and ＋39.97 mV,respec-tively. The nano-aluminum adjuvant vaccine was transparent and stable without precipitate,whereas the conventional aluminum ad-juvant vaccine was turbid and a white precipitate was visible soon. The hemagglutination inhibition （HI） titers of the nano-aluminum adjuvant group were generally higher than those of the conventional aluminum group except the titer on day 29. The results show that the nano-aluminum adjuvant has better stability and higher levels of antibodies for a longer time than the conventional aluminum adjuvant.

关 键 词：nano-aluminum adjuvant aluminum hydroxide sol Newcastle disease vaccine（NDV） hemagglutination inhibition（HI） titer 

分 类 号：S852.43[农业科学—基础兽医学]