铁叶绿酸钠微囊的制备及释放度测定  

Study on Preparation and Dissolution of Sodium-iron Chlorophyllin Microcapsules

作　　者：王丽芸[1] 刘淑萍[2] 

机构地区：[1]河北理工大学医院,河北唐山063009 [2]河北理工大学化工与生物技术学院

出　　处：《中国药师》2011年第2期210-212,共3页China Pharmacist

摘　　要：目的:制备铁叶绿酸钠微囊,并考察其体外释放情况。方法:采用优化的溶剂挥发法制备铁叶绿酸钠微囊,以正交试验确定制备工艺。结果:铁叶绿酸钠微囊的最佳制备工艺为EC与内相铁叶绿酸钠比为2:1、以1%PVA为分散剂、EC浓度为3%、搅拌速度为700 r·min^(-1)。结论:铁叶绿酸钠微囊制备方法简单,微囊具有明显的缓释作用。Objective： To study the preparation and release rate of sodium-iron chlorophyllin microcapsules. Method： Sodium-iron chlorophyllin microcapsules were prepared by solvent evaporation method optimized by orthogonal design. Result： The optimized conditions were as follows ：the ratio of EC and sodium-iron chlorophyllin in internal phase was 2：1,1% PVA was used as the dispersion medium, the coneentration of E C was 3%, and the stirring speed was 700 r.min-1. Conclusion： The preparation procedure is easy to be operated. The mieroeapsules have promising sustained release orooertv.

关 键 词：铁叶绿酸钠 微囊 溶剂挥发法 

分 类 号：R944.9[医药卫生—药剂学]