老年2型糖尿病患者血清内生肌酐清除率与代谢综合征的相关性探讨  

Relevance between endogenous creatinine clearance rate and metabolic syndrome in elderly patients with type 2 diabetes

作　　者：李美[1] 张宏[1] 朱梦瑜[2] 赵伟[1] 

机构地区：[1]天津医科大学代谢病医院肥胖代谢科 卫生部和天津市激素与发育重点实验室,300070 [2]天津医科大学基础医学院免疫教研室

出　　处：《中国医药》2011年第3期288-289,共2页China Medicine

摘　　要：目的 探讨老年2型糖尿病患者血清内生肌酐清除率（Ccr）与代谢综合征（MS）及其主要组成成分的相关性.方法 选择我院住院的老年2型糖尿病患者329例,根据有无MS分为不伴MS组（144例）和伴MS组（185例）,比较2组血清肌酐清除率,分析其与代谢综合征及其主要组成成分的相关性.结果 329例老年2型糖尿病患者中代谢综合征患病率达56.23%（185例）;与不伴MS组相比,伴MS组患者BMI、血清TG、收缩压、舒张压明显增高,HDL-C、Ccr[（105.2±28.1）比（93.1±29.1）ml/（min·1.73 m2）]明显降低（均P＜0.05）;Ccr与BMI、TG、SBP、DBP及代谢异常集聚数目呈显著负相关;调整了年龄、性别、糖尿病病程、糖化血红蛋白后,Ccr与代谢综合征及其主要组成成分中的TG、B MI、DBP呈显著负相关.结论 老年2型糖尿病患者代谢综合征患病率高,积极多因素干预治疗可能有助于糖尿病肾病的防治.Objective To investigate the relevance between endogenous creatinine clearance rate（Ccr） and metabolic syndrome and its components in elderly patients with type 2 diabetes. Methods Totally 392 elderly patients with type 2 diabetes were divided into two groups based on with/without metabolic syndrome. Compared the changes of Ccr in the two groups. The relationship between Ccr and metabolic syndrome and its components was analyzed. Results The prevalence of metabolic syndrome in 329 elderly patients with type 2 diabetes was 56.23%;compared to N MS group, the levels of body mass index （BMI）, triglyceride （TG）, systolic blood pressure（SBP）and diastolic blood pressure（DBP） in MS group increased obviously, but high density lipoprotein-cholesterol（HDLnegative correlation with BMI, TG, SBP, DBP and the number of metabolism mustering（r=-0.190, -0.277, -0.156, - 0.128, -0.214, P 〈 0.05 ）. After adjusting the age, gender, the ascend duration of diabetes and glycosylated hemoglobin A1C, Ccr had a negative correlation with metabolic syndrome and it＇s components of TG, BMI,DBP（ P〈0.05）. Conclusion There is high prevalence of metabolic syndrome in elderly patients with type 2 diabetes. It helps to prevent and treat diabetic nephropathy by controlling the levels of the components of metabolic syndrome.

关 键 词：糖尿病 2型 代谢综合征 血清内生肌酐清除率 

分 类 号：R587.1[医药卫生—内分泌]