自身抗体阴性的原发性干燥综合征行唇腺活检的临床分析  

Clinical analysis of labial salivary gland biopsy for primary Sjogren＇s syndrome with negative autoantibodies

作　　者：唐晓航[1] 于鹏[1] 白志伟[1] 祁劲松[1] 曹经一[1] 

机构地区：[1]首都医科大学附属北京朝阳医院口腔科,100020

出　　处：《中国医药》2011年第3期353-354,共2页China Medicine

摘　　要：目的 探讨如何提高自身抗体（抗SSA/SSB抗体）阴性原发干燥综合征（pSS）患者唇腺活检诊断的刚性率.方法 回顾性分析82例抗SSA/SSB抗体阴性疑似pSS患者,行同位素检查腮腺受损情况和进行唇腺活检进行确诊情况.结果 82例患者唇腺活检病理报告阳性51例（62.2%）,其中ChisholmⅢ级17例,Ⅳ级34例.51例唇腺活检阳性组中有44例（86.3%）腮腺同位素检查为中度以上受损;31例唇腺活检阴性组中有15例（48.4%）腮腺同位素检查为中度以上受损;2组之间差异有统计学意义（P＜0.01）.结论 腮腺同位素检查受损在中度以上者,唇腺活检对自身抗体阴性pSS诊断的阳性率较高.Objective To improve the diagnosis postive rate of primary Sjogren＇s syndrome （pSS） by labial salivary gland（LSG） biopsy in patients with negative autoantibodies（SSA/SSB autoantibodies）. Methods Eightytwo suspected pSS inpatients with both negative SSA/SSB autoantibodies were analyzed retrospectively. The decreased parotid gland function was tested and the LSG biopsy was performed to confirmed diagnosis. Results There were fifty-one patients（62.2% ） were LSG biopsy positive, including 17 Chisholm Ⅲ and 34 Chisholm Ⅳ in histopathologic grading. And 44（86% ） were found Parotid gland function moderate/severe damaged in the 51 LSG positive patients, moreover 15（48% ） patients were found moderate/severe damaged in 31 LSG negtive patients, A chi-square test was used between the two groups, the difference was significant （ P 〈 0.01 ）, Conclusion LSG biopsy might be sensitive in suspected pSS patients with negtive antoantibodies when the parotid gland function is moderate/severe damaged.

关 键 词：干燥综合征 唇腺活检 自身抗体 

分 类 号：R442.8[医药卫生—诊断学]