系统性红斑狼疮遗传易感性研究进展  

A review of genetic susceptibility in systemic lupus erythematosus

作　　者：郝丽霞[1] 李晓岚[1] 

机构地区：[1]昆明医学院第二附属医院皮肤性病/风湿免疫科,云南昆明650101

出　　处：《皮肤病与性病》2011年第1期21-23,27,共4页Dermatology and Venereology

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以多种自身抗体产生和继发免疫复合物沉着为特点的系统性自身免疫性疾病,研究表明本病发生受遗传、激素和环境因素共同影响。近年研究证实,遗传因素在决定此病易感性及临床表型方面起关键作用,但是在不同种族、地区,SLE发病的易感基因及其影响程度有所不同。systemic lupus erythematosus （SLE） is a systemic autoimmune disorder characterized by the production of broad variety of autoantibodies and subsequent immunecomplex deposition. Previous studies have suggested that genetic, hormonal, environmental factors contribute to the development of this disease. Several recent studies have further confirmed that genetic factor plays a critical role in determining the susceptibility and phenotype. The susceptible genes involved and the strength of their influence do, however, appear to differ considerably in different populations.

关 键 词：系统性红斑狼疮 遗传易感性 研究 

分 类 号：R593.241[医药卫生—内科学]