“C”形针刀松解术对重型肩周炎患者血清IL-6、IL-10及TNF-α的影响  

Effects of needle knife relaxing therapy on serum IL-6、IL-10 and TNF-α of severe shoulder periarthritis

作　　者：吴坛光[1] 李建华[1] 陈开文[1] 李斌[1] 胡惠英[1] 

机构地区：[1]解放军第161医院麻醉科,湖北武汉430010

出　　处：《临床军医杂志》2011年第1期104-105,共2页Clinical Journal of Medical Officers

基　　金：武汉后方基地科研基金资助项目(编号:2008-161-02)

摘　　要：目的观察"C"形针刀松解术对重型肩周炎患者血清IL-6、IL-10及TNF-α的影响,探讨其镇痛机制。方法 60例重型肩周炎患者随机分为针刀治疗组(观察组)及痛点注射组(对照组),每组各30例。观察组臂丛阻滞后行肩周"C"形针刀松解术,对照组肩周痛点注射消炎镇痛液(含曲安奈德),两组均于治疗前后采用痛觉视觉模拟评分法(visual analog scale,VAS)进行疼痛评分,同时静脉采血,以酶联免疫吸附试验(ELISA)测定血清IL-6、IL-10及TNF-α水平。结果与治疗前比较,两组治疗后VAS评分及血清IL-6、IL-10、TNF-α水平均不同程度降低(P均<0.01),组间比较差异无统计学意义(P>0.05)。结论 "C"形针刀松解术可有效解除重型肩周炎患者的疼痛症状,其机制与降低血清IL-6、IL-10及TNF-α水平有关。Objective To investigate the mechanism of needle knife relaxing therapy for severe shoulder periarthritis from the change of serum IL-6、IL-10 and TNF-α.Methods 60 patients were recruited and randomly allocated into needle knife group（n=30） and pain-point injection group（n=30）,before and after the treatment,the serum level of IL-6、IL-10 and TNF-α were measured with enzyme linked immunosorbent assay（ELISA）and VAS score were observed.Results After the treatment,there were significant decrease of VAS score and the serum level of IL-6、IL-10 and TNF-α in the needle knife group than in the pain-point injection group（P〈0.01）.Conclusion By relaxing the local contracted adhesive soft tissue,the needle knife can reduce the serum level of IL-6、IL-10、TNF-α,and then relive tension pain in the patients with severe shoulder periarthritis.

关 键 词：重型肩周炎 “C”形针刀松解术 白细胞介素6 白细胞介素10 肿瘤坏死因子-Α 

分 类 号：R684.3[医药卫生—骨科学]