NT-proBNP在呼吸困难鉴别中的应用研究  

Application of NT-proBNP in the differential diagnosis of dyspnea which caused by heart disease or pulmonary disease

作　　者：陈阵[1] 孙国华[1] 孙芹敏[1] 李民[2] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116011 [2]解放军第210医院检验科,辽宁大连116021

出　　处：《临床军医杂志》2011年第1期129-131,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨N末端脑钠肽(NT-proBNP)对心源性和肺源性呼吸困难的鉴别价值。方法用酶免疫分析法测定100例呼吸困难患者血浆中的NT-proBNP浓度,包括心源性呼吸困难和肺源性呼吸困难,观察两组患者血浆NT-proBNP的浓度。同时测定50例健康体检者的NT-proBNP浓度作为对照组做比较分析。结果两组患者的BNP浓度,心源性呼吸困难组(2 932.80±1 808.44)ng/L明显高于肺源性呼吸困难组(282.73±239.05)ng/L,两组差异有显著性意义(P<0.01)。结论 NT-proBNP可作为鉴别心源性呼吸困难和肺源性呼吸困难的一个客观指标,其方法简单快速、特异性好、敏感性高,具有显著的临床意义。Objective To investigate the value of NT-proBNP in the differential diagnosis of dyspnea caused by heart disease or pulmonary disease.Methods The NT-proBNP of patients suffered from dyspnea which caused by heart failure or pulmonary disease were measured by immunoenzymometric assay and compared the results.Choose 50 health examples with medical examine as control group,and measured their plasma NT-proBNP level to make comparison analysis.Results The NT-proBNP level of the patients whose dyspnea were caused by heart disease（2932.80±1808.44）n/L were obviously higher than those of patients whose dyspnea were caused by pulmonary disease（282.73±239.05）n/L,there were significant differences between the two groups（P〈0.01）.Conclusion NT-proBNP,which has remarkable clinical significance,can be used as the indicator in the differential diagnosis of dyspnea because of its highly sensitivity and specificity.

关 键 词：N末端脑钠肽 呼吸困难 心力衰竭 

分 类 号：R441.8[医药卫生—诊断学]