动态监测C-反应蛋白在早产儿院内感染中的临床应用  

The effect of CRP on dynamic monitoring nosocomial infection in preterm newborns

作　　者：马雪莲[1] 黄静[1] 

机构地区：[1]浙江省绍兴市妇幼保健院检验科,浙江绍兴312000

出　　处：《中国卫生检验杂志》2011年第2期448-449,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨C-反应蛋白(CRP)在早产儿院内感染中的动态变化及应用。方法:住院190例早产儿(≤35周)院内感染监测中,动态检测其在病程1 d、3 d、7 d、10 d CRP水平。结果:发生院内感染早产儿病程初期CRP明显增高,3 d左右达最高峰,与对照组相比,有显著差异(P<0.01)。经有效治疗后CRP开始下降,7 d左右仍高于正常,与对照组相比,有显著差异(P<0.05)。有效治疗10 d后,CRP基本降至正常,与对照组相比无显著差异。结论:早产儿CRP的动态变化能更敏感地监测到院内感染的发生,对其诊断具较高临床价值。Objective：To study the clinical effect of CRP on dynamic monitoring of nosocomial infection in preterm newborns.Methods： 190 newborns of less than 35 weeds′gestational age in our hospital were involved in the study,the concentration of CPR at 1 d、3 d、7 d、10 d during the course of disease were examined.Results： There were obviously increased concentration of CRP in preterm infants with defined nosocomial infection in the early stage,and CRP level reached a maximum at 3 d,which was significantly higher compared with normal controls（P0.01）,then it decreased at 7 d after effective treatment,but it was still significantly higher compared with normal controls（P0.05）.The CRP level decreased to normal range at 10 d after treatment,and there was no significant difference compared with normal controls.Conclusion： The results indicate that the use of dynamic monitoring CRP concentration in preterm infants can increase the sensitivity of nosoeomial infection diagnosis,and it is more effective and worth popularization.

关 键 词：C-反应蛋白 早产儿 院内感染 

分 类 号：R722.6[医药卫生—儿科]