Noise-induced synchronous stochastic oscillations in small scale cultured heart-cell networks  

作　　者：袁岚 刘志强 张慧敏 丁学利 杨明浩 古华光 任维 

机构地区：[1]College of Life Science,Shaanxi Normal University

出　　处：《Chinese Physics B》2011年第2期133-147,共15页中国物理B（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 10772101 and 30670533);the National High Technology Research and Development Program of China (Grant No. 2007AA02Z310);the Fundamental Research Funds for the Central Universities (Grant No. GK200902025)

摘　　要：This paper reports that the synchronous integer multiple oscillations of heart-cell networks or clusters are observed in the biology experiment. The behaviour of the integer multiple rhythm is a transition between super- and sub- threshold oscillations, the stochastic mechanism of the transition is identified. The similar synchronized oscillations are theoretically reproduced in the stochastic network composed of heterogeneous cells whose behaviours are chosen as excitable or oscillatory states near a Hopf bifurcation point. The parameter regions of coupling strength and noise density that the complex oscillatory rhythms can be simulated are identified. The results show that the rhythm results from a simple stochastic alternating process between super- and sub-threshold oscillations. Studies on single heart cells forming these clusters reveal excitable or oscillatory state nearby a Hopf bifurcation point underpinning the stochastic alternation. In discussion, the results are related to some abnormal heartbeat rhythms such as the sinus arrest.This paper reports that the synchronous integer multiple oscillations of heart-cell networks or clusters are observed in the biology experiment. The behaviour of the integer multiple rhythm is a transition between super- and sub- threshold oscillations, the stochastic mechanism of the transition is identified. The similar synchronized oscillations are theoretically reproduced in the stochastic network composed of heterogeneous cells whose behaviours are chosen as excitable or oscillatory states near a Hopf bifurcation point. The parameter regions of coupling strength and noise density that the complex oscillatory rhythms can be simulated are identified. The results show that the rhythm results from a simple stochastic alternating process between super- and sub-threshold oscillations. Studies on single heart cells forming these clusters reveal excitable or oscillatory state nearby a Hopf bifurcation point underpinning the stochastic alternation. In discussion, the results are related to some abnormal heartbeat rhythms such as the sinus arrest.

关 键 词：synchronous oscillation network Hopf bifurcation effect of noise integer multiple rhythms heart cell 

分 类 号：N93[自然科学总论]