武汉市弓形虫IgM阳性孕妇异常妊娠结局研究  

STUDY OF ABNORMAL PREGNANCY OUTCOME AMONG TOXOPLASMA IGM-POSITIVE PREGNANT WOMEN IN WUHAN

作　　者：索庆丽[1] 刘胜武[2] 姚婷[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心,武汉430016 [2]武汉大学基础医学院免疫学教研室

出　　处：《现代预防医学》2011年第5期863-865,868,共4页Modern Preventive Medicine

摘　　要：[目的]摸清武汉市孕妇TOX感染率和TOX-IgM阳性孕妇异常妊娠状况,为预防和治疗孕妇TOX感染提供参考依据。[方法]取孕妇血清1ml,用ELISA法检测血清中TOX-IgM和TOX-IgG,对TOX-IgM阳性孕妇和TOX-IgM阴性对照组孕妇妊娠状况和结局进行定期追踪,采用两组或多组比较χ2检验进行统计分析。[结果]孕妇TOX-IgM阳性率为5.50%,早孕和中晚TOX-IgM阳性孕妇异常妊娠百分比显著高于对照组孕妇的百分比,在TOX感染引起的异常妊娠中,流产和晚期流产居首位,其次是胎死宫内,胎儿宫内发育迟缓排第3位,胎儿神经系统畸形排第4位,早产最低。[结论]TOX感染可导致异常妊娠结局的发生,医疗保健机构要加强TOX防治知识的宣教,培养育龄期妇女良好生活和饮食习惯,针对孕妇感染特点,加强孕期各阶段的监测和防治工作,减少不良妊娠结局的发生,提高出生人口素质。[Objective]To find out the TOX infection rate among pregnant women and abnormal pregnancy status in TOX-IgM positive pregnant women in Wuhan,to provide references to prevent and treat Toxoplasma infected pregnant women.[Methods]Took pregnancy serum 1 ml,detected serum TOX-IgM and TOX-IgG with ELISA method.Track the pregnancy outcomes between TOX-IgM positive and negative pregnant respective during early,middle and late pregnancy.Statistic analysis was applied by Chi-square test.[Results]The TOX-IgM positive rate was 5.50% in pregnant women.The percentage of abnormal pregnancy among TOX-IgM positive pregnant women was significantly higher than the negative control group of pregnant women in every period of pregnancy.Abortion and late abortion constituted the highest ratio,followed by fetal death,the third was the intrauterine growth retardation.Fetal nervous system malformation（fetal hydrocephalus,fetal microcephaly,anencephaly and fetal brain meningocele）was the fourth.Premature ratio was relatively low.[Conclusion]TOX infection may lead to the occurrence of abnormal pregnancy outcome,health care institutions should strengthen the publicity of prevention and treatment on TOX knowledge,cultivate good living and eating habits of women at childbearing age.It should reinforce prevention and cure measures during every period of pregnancy based on characteristics of TOX to reduce the birth defect occurrence and improve the quality of the population.

关 键 词：弓形虫 孕妇 异常妊娠 结局 

分 类 号：R382.5[医药卫生—医学寄生虫学]