极低出生体重儿支气管肺发育不良的高危因素  

THE HIGH-RISK FACTORS OF BRONCHOPULMONARY DYSPLASIA AMONG VERY LOW BIRTH WEIGHT INFANT

作　　者：邵予[1] 祝万君[2] 李有国[2] 

机构地区：[1]深圳市龙岗区妇幼保健院,深圳518172 [2]深圳市龙岗区人民医院

出　　处：《现代预防医学》2011年第5期869-870,875,共3页Modern Preventive Medicine

摘　　要：[目的]分析极低出生体重儿(VLBWI)罹患支气管肺发育不良(BPD)的高危因素。[方法]回顾性分析某院新生儿重症监护室近6年期间,出生体重≤1500g,胎龄≤36周并且存活时间≥28d的VLBWI69例病史资料。比较27例BPD(BPD组)和42例非BPD(对照组)VLBWI胎龄、出生体重、新生儿呼吸窘迫综合征(NRDS)、机械通气时间、生后24～48h液体摄取量、反复肺部感染情况。[结果]单因素分析显示,胎龄小、极低出生体重、NRDS、机械通气时间≥10d、反复肺部感染是VLBWI罹患BPD的独立危险因素(P﹤0.05);多因素Logistic回归分析显示,胎龄是VLBWI罹患BPD的高危因素(OR=0.656,P=0.031)。[结论]避免极低体重早产儿长时间机械通气和有效控制肺部感染是防治BPD的关键。[Objective]To analyze the high-risk factors of bronchopulmonary dysplasia among very low birth weight infant（VLBWI）.[Methods]The cases of 69 VLBWI whose birth weight≤1 500 g,age≤36 weeks and survival time ≥28 days admitted to neonatal intensive care unit in our hospital in the last 6 years were analyzed retrospectively.Compared gestational age,birth weight,neonatal respiratory distress syndrome,mechanical ventilation time,24-48 h liquid intake after birth and repeated lung infection among 27 cases of BPD（BPD group）and 42 patients with non-BPD（control group）VLBWI.[Results]Univariate analysis showed that young gestational age,low birth weight,mechanical ventilation≥10d,and repeated lung infections were independent risk factors for BPD incidence（P﹤0.05）;Multivariate Logistic regression showed that gestational age was the high risk factor for VLBWI suffering from BPD（OR = 0.656,P = 0.031）.[Conclusion]Avoiding prolonged mechanical ventilation of the very low birth weight and/or premature birth infants and effectively controlling pulmonary infection are the keys for BPD prevention and treatment.

关 键 词：极低出生体重儿 胎龄 出生体重 支气管肺发育不良 高危因素 

分 类 号：R174[医药卫生—妇幼卫生保健]