丹红注射液和丹参多酚酸盐治疗慢性肾功能不全的随机对照研究  

Randomized controlled trials of Danhong Injection and salvianolate in treatment of chronic renal insufficiency

作　　者：李娟[1] 郭志勇[1] 吴海洋[1] 孙婧[1] 

机构地区：[1]上海第二军医大学附属长海医院,上海200433

出　　处：《现代中西医结合杂志》2011年第9期1048-1050,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的比较丹红注射液和丹参多酚酸盐治疗早期慢性肾功能不全的临床疗效及安全性。方法按照纳入标准选择病例,并随机分为2组。A组给予丹红注射液治疗,B组给予丹参多酚酸盐注射液治疗,疗程为7 d。比较2组治疗前后血脂和肾功能的变化情况和不良反应的发生情况。结果治疗后2组患者的血脂(血胆固醇、低密度脂蛋白)、肾功能(血肌酐、尿素氮、肾小球滤过率、尿蛋白)均有明显改善(P均<0.05),A组肾功能的改善程度优于B组(P均<0.05)。A组及B组分别出现1例静脉炎,未见其他不良反应。结论丹红注射液可显著降低血脂、减少尿蛋白、改善患者的肾功能,而且其疗效优于丹参多酚酸盐。Objective It is to evaluate the effectiveness and safety of Danhong injection and salvianolate in the treatment of early chronic renal insufficiency.Methods Qualified patients were randomly divided into two groups.Group A were treated by Danhong injection,Group B were treated by salvianolate,which lasted for 7 days.The related parameters of blood fat,renal function and side effects were monitored before treatment and in the 8th day after treatment.Results After treatment,blood fat（TC,LDL）,renal function（SCr,BUN,eGFR,urine protein） were significantly improved in group A and group B（P0.05）,and the improvement was more significant in group A（P0.05）.One case of phlebitis was found in each group,with no incidence of other side effect.Conclusion Danhong injection is superior to salvianolate in the treatment of chronic renal insufficiency in view of improvement of blood fat and renal function.

关 键 词：丹红注射液 丹参多酚酸盐 慢性肾功能不全 随机对照研究 

分 类 号：R692.5[医药卫生—泌尿科学]