慢性乙型肝炎血清HBVDNA临床诊断与病理分度的关系  

Relation between HBVDNA,clinical diagnosis and pathological degree in chronic hepatitis B.

作　　者：申遂科 王林杰[2] 

机构地区：[1]河南省汝州市第一人民医院传染科,467500 [2]解放军第三二医院病理科

出　　处：《临床肝胆病杂志》1999年第4期220-221,共2页Journal of Clinical Hepatology

摘　　要：为探讨慢性乙型肝炎时血清ＨＢＶＤＮＡ 与病理分度，临床诊断和病理分度的关系。对１４０ 例慢性乙型肝炎患者进行ＨＢＶＤＮＡ 检测、肝活检，行临床诊断与病理分度对照，ＨＢＶＤＮＡ阴、阳组间比较。结果显示临床诊断与病理分度符合率，慢轻肝７５－８％ ，慢中肝４３－２８％ ，慢重肝不符合。ＨＢＶＤＮＡ 阳性组病变程度明显加重，差异显著。随炎症活动度增加，ＡＬＴ 值升高愈明显。结论提示临床慢性中重度患者应行病理检查。ＡＬＴ 仍是观察炎症变化的敏感指标。对血清ＨＢＶＤＮＡ阳性者抗病毒治疗是必要的。To investigate the association of HBVDNA and clinical diagnosis with pathological degree in chronic hepatitis B.We examined 140 patients with chronic hepatitis B comparing the clinical diagnosis with pathological degree.We compared pathological degree of between the positive HBVDNA group and the negative HBVDNA group.Results showed accordance of the mild,medium and severe changes was 75 8% 43 24% and 0 respclively.Serum ALT was more correlated with the inflammatory activity.The lesion of the positive HBVDNA group is more severe than that of the negative HBVDNA group.The patients with clinical medium severe lesion have to do pathological examination.Serum ALT is the sensitive sign for the inflammatory acetivity antiviral therapy is necessary for the positive HBVDNA patients.

关 键 词：慢性乙型肝炎 HBVDNA ALT病理分度 临床诊断 

分 类 号：R512.620.4[医药卫生—内科学]