HBV特异性T细胞治疗慢性乙型肝炎的研究  

Study of Treating Chronic Hepatitis B by Transfusing Hepatitis B Virus Specific T cells

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作  者:黄梅芳[1] 张春兰[1] 袁小珍[1] 

机构地区:[1]广州市第八人民医院传染病研究所,510060

出  处:《临床肝胆病杂志》1999年第4期230-231,229,共3页Journal of Clinical Hepatology

摘  要:为寻求一种治疗慢性乙型肝炎的新方法,应用HBV 特异性T 细胞输注治疗慢性乙型肝炎9 例。结果显示,在疗程结束后,患者的HBsAg、HBeAg、HBVDNA 的含量均有所下降。其中HBeAg 下降较明显,P< 0-01 。2 例HBcAg 阳性患者,HBcAg 阴转。CD3+ 、CD4+ 、CD4 + /CD8 + 、NK活性上升,CD8+ 、sIL- 2R 较治疗前有所回复。表明特异性T 细胞治疗慢性乙型肝炎有一定疗效,远期疗效在观察中。In order to seek a new method for treating chronic hepatitis B,9 cases of chronic hepatitis B were treated by transfusing hepatitis B virus antigen specific T cclls.The results showed that after the treatment level of HBsAg、HBeAg and HBV DNA in sera of patients with chronic hepatitis B decreased in some degree,and level of HBe Ag in sera decreased more remarkably than that of HBsAg and HBV DNA,(P<0 01)HBcAg of 2 cases changed from positive to negative.Frequencies of CD 3 +、CD 4 +、CD 4 +/CD 8 + T cells and NK cells in sera were increased mean while frequency of CD 8 + T cells and sIL-2R level in sera were decreased to normal levels.The results suggest that transfusion of hepatitis B virus antigen specific T cells have effects in some extent for treating chronic hepatitis B.

关 键 词:慢性 乙型肝炎 HBV特异性 T细胞 SIL-2R 治疗 

分 类 号:R512.620.5[医药卫生—内科学]

 

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