肝硬化基础上原发性肝癌的时间密度曲线研究  

The time-density curve study of primary hepatocellular carcinoma based on cirrhosis with MSCT

作　　者：方心华[1] 钟群[2,3] 赵春雷[2,3] 钱根年[2,3] 陈自谦[2,3] 张雪林[4] 

机构地区：[1]解放军184医院放射科,江西鹰潭335400 [2]厦门大学附属东方医院 [3]南京军区福州总医院医学影像中心,福建福州350025 [4]南方医科大学附属第一医院,广东广州510515

出　　处：《医学影像学杂志》2011年第2期221-224,共4页Journal of Medical Imaging

基　　金：福建省青年人才创新项目(2006F3105)

摘　　要：目的:应用MSCT的时间密度曲线(TDC)研究发生于肝硬化基础的肝癌的达峰时间(TTP)及峰值高度(PV)的变化,揭示癌变的血流动力学改变。方法:肝炎后肝硬化合并原发性肝癌病例32例,行MSCT动态增强扫描,观察时间密度曲线及分别得到TTP及PV,应用配对t检验进行统计学分析。结果:肝硬化实质与肝癌的TDC形态不同,两者之间TTP及PV均P<0.05,有统计学意义,即肝癌强化早而强化程度低于肝脏实质。结论:通过肝硬化及肝癌TDC形态学及其指标TTP与PV明确提示它们不同的血流动力学变化。Objective：To explore the time-density curve（TDC） changes of primary hepatocellular carcinoma based on hepatic cirrhosis with MSCT and to study the differences of TTP and PV between HCC and hepatic parenchyma so that to reveal the hemodynamic change betreen them.Methods：Thirty-two cases were primary hepatocellular carcinoma based on cirrhosis.The target scans of each case were performed dynamic scanning within total 30 times.And the TDCs were got and all cases＇ time to peak（TTP） and peak value（PV） of hepatic parenchyma and HCC were obtained.The paired-sample test was applied to determine difference of TTP/PV between hepatic parenchyma and PHC mass.Results：The TDC tendency of hepatic parenchyma and PHC were different.Significant differences of the TTP and PV were observed between hepatic parenchyma and HCC（P〈0.05,respectively）.Compared with the TTP and PV of hepatic parenchyma,the mass decreased.Conclusion：TDC,TTP and PV can represent hemodynamic changes of HCC based on cirrhosis.

关 键 词：体层摄影术 X线计算机 肝硬化 原发性肝癌 时间密度曲线 

分 类 号：R814.42[医药卫生—影像医学与核医学] R575.2[医药卫生—放射医学]