阿苯达唑脂质体对小鼠细粒棘球蚴囊超微结构的影响  

EFFECT OF LIPOSOMAL ALBENDAZOLE ON THE ULTRASTRUCTURE OF ECHINOCOCCUS GRANULOSUS CYSTS IN MICE

作　　者：邵英梅[1] 刘文杰[2] 温浩[1] 

机构地区：[1]新疆医学院第一附属医院普外科,乌鲁木齐830000 [2]新疆医学院电子显微镜室,乌鲁木齐830000

出　　处：《中国寄生虫学与寄生虫病杂志》1999年第5期292-293,共2页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：目的:探讨阿苯达唑脂质体(liposom alalbendazole,L-ABZ)及其联合西咪替丁(cim etidine,CTD)治疗小鼠细粒棘球蚴病的病理形态变化。方法:将阿苯达唑脂质体及西咪替丁(1.5% 乳液阿苯达唑200 m g/kg,西咪替丁100 m g/kg),经口灌喂感染小鼠3个月后,用光镜和电镜观察小鼠肝、腹细粒棘球蚴囊结构的病理改变。结果:以阿苯达唑脂质体联合西咪替丁治疗组细粒棘球蚴囊组织变性坏死改变最为显著,与对照组有显著性差异(P< 0.01)。结论:脂质体包封阿苯达唑,可提高阿苯达唑的抗细粒棘球蚴作用。AIM:To observe the histopathological changes of Echinococcus granulosus cysts in mice treated with liposomal albendazole and co administration with cimetidine by light microscopy and electron microscopy. METHODS:An oral dose of liposomal ABZ with different formulations was given at 200 mg/kg·d.Cimetidine was administered daily at an oral dose of 100 mg/kg·d. Sixty seven mice were orally given different drugs six days per week for a total of twelve weeks. RESULTS: The histopathological changes indicated that there were significant differences ( P <0.01) between treated groups and control group. The degeneration and necrosis of E.granulosus cysts were marked in liposomal albendazole combined with cimetidin group. CONCLUSION:Liposomal albendazole was more effective against E.granulosus cyst than albendazole. Cimetidine had an apparent synergistic effect when given in combination with liposomal albendazle.

关 键 词：动物实验 细粒棘球蚴 阿苯达唑脂质体 透射电镜 

分 类 号：R383.33[医药卫生—医学寄生虫学]