MNW基质液及MNW对免疫细胞功能的影响  

Effects of MNW and its matrix on the functions of immune cells

作　　者：孙万邦[1] 欧刚卫[1] 王大忠[1] 王燕妮[1] 张忆雄[1] 李官成[1] 王平金 丁勇 

机构地区：[1]遵义医学院 [2]贵州仁怀海洋滋补酒有限公司

出　　处：《遵义医学院学报》1999年第4期271-273,共3页Journal of Zunyi Medical University

摘　　要：目的以海洋动植物为原料制备MNW基质液，研究MNW基质液与MNW对免疫细胞功能的影响。方法以MNW基质液和MNW分别灌胃BALB／C小鼠和NLH小鼠，观察小鼠巨噬细胞吞噬率、吞噬指数。以MNW基质液诱导T细胞，以125I－UdR掺入法观察MNW基质液对人外周血T细胞增殖的影响，以及MNW对小鼠NK细胞活性的影响。结果MNW基质液能增强BALB／C和NLH小鼠吞噬率和吞噬指数。MNW中，高剂量组能提高BALB／C小鼠的吞噬率和吞噬指数。MNW基质液能协同诱导人外周血T细胞增殖。MNW对BALB／C小鼠NK活性影响，低剂量组与对照组NK细胞活性有显著性差异，中、高剂量组活性明显增高。结论MNW及基质液均能增加小鼠吞噬功能，能增加NK细胞活性，能协同诱导人外周T细胞增殖，具有调节免疫细胞的功能。Objective To extracted MNW matrix from severa marine animals and weeds; to study theimmune effects of MNW (Marine nourishing Wine) and MNW matrix on immune cells. MethodsFeeding the mice BALB/C and NLH respectively with MNW matrix and MNW directly into theirstomach, then observing changes of phagoctic rate and phagocytic index. Treating T lymphocytes withMNW matrix, then viewing the effects of MNW matrix on the proliferation of T lymphocytes of humanperiperal blood with 125I-UdR interblending and the effects of MNW on the activity of NK cells. ResultsMNW matrix could promote the phagocytic rate and phagocytic index of T cells of BALB/C and NLHmice. Among the MW groups, the promtion of phagpcytic rate and phagocytic index could be viewedin the high dose group. MNW matrix could induce the proliferation of T cells of human periperal bloodsynergically. MNW might have the effects of promting the activity of NK celis of BALB/C mice,among which the low dose group had significant difference from the contrast and the middle and highdose groups had highly significant difference fron the contrast. Conclusions MNW and MNWmatrixcould both enhance the phagocytic function of mice and in the experiments and the activity of NK cells,and could induce the proliferation of T cells, which proved that they both have the functions of immuneadjustment.

关 键 词：海洋生物 滋补酒 MNW基质液 免疫功能 

分 类 号：R931.77[医药卫生—生药学]