3′-大豆苷元磺酸钠对大鼠脑缺血/再灌注损伤时IL-6的影响  

Effects of 3'-daidzein Sulfonate Sodiumon Serum IL-6 Level in Cerebral Ischemia/Reperfusion Injury Rats

作　　者：钟声[1] 曾靖[2] 李良东[2] 黄志华[2] 肖海[2] 魏桂林[1] 赖燕蔚[1] 

机构地区：[1]赣南医学院第一附属医院,江西赣州341000 [2]赣南医学院,江西赣州341000

出　　处：《时珍国医国药》2011年第2期292-293,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30760284)

摘　　要：目的研究3′-大豆苷元磺酸钠对大鼠脑缺血/再灌注损伤时IL-6的影响。方法大鼠大脑中动脉栓塞,制作脑缺血再灌注损伤模型,缺血后10 min,于舌下静脉给不同剂量的3′-大豆苷元磺酸钠。再灌注24 h后,断头取脑,TTC染色,测定脑梗塞体积;取前脑称湿重,烘干后称干重,计算脑组织含水量;取血2 ml,离心后,取血清,放免法测血清IL-6含量。结果与模型组相比,3′-大豆苷元磺酸钠治疗组脑梗塞体积减小,脑组织含水量降低,脑组织IL-6含量降低。结论 3′-大豆苷元磺酸钠对脑缺血再灌注损伤具有明显的保护作用,其保护机制与减少炎性细胞因子IL-6的表达有关。Objective To explore the therapeutic effects of 3＇-daidzein sulfonate sodium on cerebral ischemia/reperfusion injury in rats.Methods A rat ischemia/reperfusion injury was established through embolization of the middle cerebral artery,and the injury rats were treated with 3＇-daidzein sulfonate sodium by sublingual vein injection.The infarction volume,water content,and the level of IL-6 in brain tissue were measured.Results After treatment,the rats with cerebral ischemia/reperfusion injury showed a decrease in the infarction volumes,water content,and IL-6 level.Conclusion 3＇-daidzein sulfonate sodium has a therapeutic effect on rat cerebral ischemia/reperfusion injury by down-regulating IL-6 release.

关 键 词：3′-大豆苷元磺酸钠 脑缺血再灌注损伤 IL-6 

分 类 号：R285.5[医药卫生—中药学]