Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers  

大麻酚类受体拮抗剂SR141716A减少乙醇蒸气室中大鼠的自发反应性乙醇自身给药行为

作　　者：Feinando RODRIGUEZ DE FONSECA Amanda J ROBERTS Ainhoa BILBAO George F KOOB Miguel NAVARRO 

机构地区：[1]Instituto Complutense de Drogodependencias,Departamenta de Psicobiologia,Facultad de Psicologia,Universidad Complutense de Madrid,28223-Madrid,Spain [2]Department of Neuropharmacology,The Scripps Research Institute,La Jolla CA 92037,USA

出　　处：《中国药理学报》1999年第12期1109-1114,共6页Acta Pharmacologica Sinica

基　　金：DGICYT PM 96/0047,Comunidad de Madrid and Plan Nacional Sobre Drogas(MN,FRF);National Institutes of Health grants AA 06420;AA 08459 from the National Institute on Alcohol Abuse and Alcoholism(GFK and AJR)

摘　　要：AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.

关 键 词：ETHANOL self administration cannabinoid rcceptors SR141716A 

分 类 号：R971.2[医药卫生—药品]