甲亢患者^(131)Ⅰ治疗前血清TGAb和TPOAb含量与早发甲减关系的探讨  

Correlation between the serum levels of TPOAb and TGAb in patients with hyperthyroidism and the incidence of the early hypothyroidism

作　　者：王超群[1] 杨军[1] 谢彦[1] 杨继文[1] 葛俊亮[1] 程光华[1] 

机构地区：[1]皖南医学院附属弋矶山医院核医学科,安徽芜湖241001

出　　处：《皖南医学院学报》2011年第1期25-27,共3页Journal of Wannan Medical College

摘　　要：目的:测定放射性^(131)Ⅰ治疗前甲亢患者血清甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)水平,探讨其在^(131)Ⅰ治疗后与早发甲减发生的关系。方法:根据^(131)Ⅰ治疗前TPOAb、TGAb的检测结果,将165例患者分成3组:双阴组10例,单阳组26例,双阳组129例,比较各组间早发甲减的发生率;再将双阳组的129例患者,按TPOAb、TGAb滴度水平的高低分成3组:A组66例,B组54例,C组9例,进一步探讨^(131)Ⅰ治疗前TPOAb、TGAb滴度水平的高低与早发甲减的关系。结果:^(131)Ⅰ治疗后的165例患者,各组间早发甲减发生率差异无统计学意义(χ2=1.35,P>0.05)。双阳组的129例患者,按TPOAb、TGAb滴度水平高低分成3组,各组间早发甲减发生率差异无统计学意义(χ2=0.89,P>0.05)。结论:TGAb、TPOAb滴度水平的高低,对于甲亢^(131)Ⅰ治疗后早发甲减的预测参考价值不大。Objective：To investigate the correlation between the serum levels of thyroid peroxidase antibody（TPOAb） and thyroglobulin antibody（TGAb） of patients with hyperthyroidism before ^（131）Ⅰtherapy and the incidence of the early hypothyroidism after ^（131）Ⅰ intervention.Methods：By negative or positive results of TPOAb and TGAb,165 patients with hyperthyroidism were divided into groups of negative TPOAb and TGAb（n=10）,positive TPOAband TGAb（n=26） and positive both TPOAb and TGAb（n=129）,and the incidence of early hypothyroidism was compared among the three groups after ^（131）Ⅰ therapy.Further,the 129 cases with positive TPOAb and TGAb were sub-divided into three groups by level of TPOAb and TGAb,i.e.,group A（n=66）,B（n=54） and C（n=9）,for examining the relationship of the levels of TPOAb and TGAb before undergoing treatment of early hypothyroidism.Results：There was no significant differences concerning the incidences of early hypothyroidism among three groups（χ2=1.35,P0.05） and the similar results were found in the 3 sub-groups（χ2=0.89,P0.05）.Conclusion：The serum levels of TPOAb and TGAb seem to have little implication in estimating the incidence of the early hypothyroidism after ^（131）Ⅰ therapy for patients with hyperthyroidism.

关 键 词：甲状腺功能亢进症 碘放射性同位素 自身抗体 早发甲减 

分 类 号：R581.1[医药卫生—内分泌]