益生菌对低体重早产儿喂养不耐受和生长发育的影响  

Clinical investigation of prebiotics on feeding intolerance and early growth in preterm infants with low birth weight

作　　者：许东宝[1] 汪浩文[1] 祝选娇[1] 黄玮[1] 胡海英[1] 

机构地区：[1]池州市人民医院新生儿科,安徽池州247000

出　　处：《皖南医学院学报》2011年第1期48-50,共3页Journal of Wannan Medical College

基　　金：池州市2010年度科技计划(社会发展)项目

摘　　要：目的:探讨益生菌制剂对早产儿喂养不耐受和生长发育的影响。方法:将70例2.5kg以下的早产低体重儿随机分成治疗组和对照组,每组35例。两组患儿均给予常规治疗,治疗组生后24 h内口服益生菌制剂(培菲康),记录两组肠道营养达418.4 kJ/(kg.d)时间,恢复出生体重时间,出生满28 d时两组患儿头围、体质量、胃肠不耐受发生率及持续时间。结果:肠道营养达418.4 kJ/(kg.d)时间、恢复出生体重时间治疗组与对照组相比较差异具有统计学意义(P<0.05);治疗组满28 d时头围、体质量较对照组显著增高,而胃肠不耐受发生率及胃肠不耐受持续时间较对照组有显著降低(P<0.05)。结论:培菲康可以改善胃肠不耐受,缩短肠道营养达418.4 kJ/(kg.d)时间及恢复至出生时的体质量时间,使头围和体质量快速增加,促进早产儿的生长发育。Objective：To explore the effects of prebiotics on the feeding intolerance and early growth and development in premature infants.Methods：Seventy premature infants under 2.5 kg were randomly assigned into groups of intervention（n=35） and controls（n=35） by conventional therapy.The intervention group were given oral intake of prebiotics in 24 h after birth,and the data were kept in the two groups concerning the time of reaching 418.4 kJ/（kg·d） by enteral feeing,days to regain birth weight,head circumference at the 28th day after birth,body weight,incidence of feeding intolerance and duration of this event.Results： The two groups were different regarding the time of reaching enteral nutrition of 418.4 kJ/（kg·d） and days to regain birth weight（P0.05）.The head circumference by the 28 th day after birth and body weight were increased,yet the incidence of feeding intolerance and its duration were decreased,as compared with the controls（P0.05）.Conclusion：Prebiotics can reduce the incidence of feeding intolerance,reduce the time of reaching 418.4 kJ/（kg·d） by enteral feeding,shorten the days to regain birth weight,but increase the head circumference and body weight and improve the early growth and development of preterm infants.

关 键 词：益生菌 喂养不耐受 生长发育 早产儿 

分 类 号：R722.6[医药卫生—儿科]