关节活络方对家兔膝关节创伤性骨化性肌炎的预防作用  

Preventive Effects of Guanjie Houluo Fang on Traumatic Myositis Ossificans in Rabbits' Knee Joint

作　　者：陈渭良[1] 邓柏杰[1] 何秋月[1] 香卫红[1] 张继平[1] 谭光明[1] 

机构地区：[1]佛山市中医院骨伤科研究所,广东佛山528000

出　　处：《中国骨伤》1999年第6期19-21,共3页China Journal of Orthopaedics and Traumatology

基　　金：广东省中医药管理局科研基金!资助课题 (编号 :粤 90 - 92 )

摘　　要：目的　探讨关节活络方对家兔膝关节创伤性骨化性肌炎的预防作用。方法　将家兔 2 0只随机分为二组 ,固定专人以特定方法进行强力被动牵拉、暴力按摩 ,然后固定 ,以复制家兔膝关节创伤性骨化性肌炎动物模型 ;同时用药组灌服关节活络方 (生药 9.2 g/ kg) ,空白组灌服等体积的蒸馏水 (9.2 ml/ kg) ,每天 1次 ,连续 9周。检测家兔皮温、肿胀度、局部骨化情况、血钙、血磷、降钙素和骨钙素及患肢肌肉组织学变化。结果　用药组 4周后肿胀度和 7周后骨化程度都明显比空白组低 (P<0 .0 5) ;用药组肌肉组织内增生的纤维组织局部有骨化倾向并形成类软骨样组织 ,但无明显骨化出现 ,而空白组肌肉间组织广泛水肿 ,纤维组织增生明显 ,并形成类骨组织和类软骨组织 ,局部出现较明显的骨化 ;而该药对局部皮温、血钙、血磷、降钙素和骨钙素无明显影响。结论　关节活络方能减缓创伤性骨化性肌炎的发生与发展 。Objective To observe the preventive effects of Guanjie Houluo Fang (GJHLF) on traumatic myositis ossificans in rabbits' knee joints Methods Twenty rabbits were randomly divided into two groups The rabbits were passively drawn and violently massaged by specialized people and, then, they were fixed to duplicate the model of traumatic myositis ossificans. The treated group was fed on GJHLF (9 2g/kg), once a day and last 9 weeks The blank group was fed on distilled water (9 2ml/kg) at the same time. Local skin temperature, degree of swelling, local ossification, blood calcium, blood phosphorus, calcitonin, osteocalin and the pathologic changes in the muscle were examined.Results Both the degree of the swelling after four weeks and the degree of the ossification after seven weeks in the treated group were markedly decreased than the blank group ( P <0 05).In the tceated group, the proliferated fibrous tissues in the muscles showed a tendency to ossify locally, cartilaginoid tissues were formed, but ossification was not obvious In the blank group, edema of muscular tissues was extensive, proliferation of fibrous tissue was evident, osteoid tissue and cartilaginoid tissue were formed, ossification appeared obviously in local region. But the effects of GJHLF on local skin temperature, blood calcium, blood phophorus, calcitonin and osteocalin were not significant [WT5”,6HZ]Conclusion [WT5”,6BZ]It is suggested that GJHLF could prevent the occurrence and development of traumatic myositis ossificans in rabbits There might be certain protective effect against myositis ossificans with GJHLF.

关 键 词：关节活络方 骨化性肌炎 动物模型 中医药疗法 

分 类 号：R274.952[医药卫生—中西医结合]