辛伐他汀、氨氯地平对实验性兔动脉粥样硬化进程中NOS/NO系统的影响  

Effects of simvastatin and amlodipine on nitric oxide synthase/nitric oxide system in atherosclerosis model of rabbit

作　　者：戴琳[1] 于清霞[2] 王辉[2] 周少玲[2] 

机构地区：[1]烟台市烟台山医院心电科,山东省264001 [2]青岛大学医学院附属烟台毓璜顶医院ICU

出　　处：《中华临床医师杂志（电子版）》2011年第3期75-77,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨诱导型一氧化氮合酶(iNOS)-一氧化氮(NO)系统在动脉粥样硬化进程中的变化、相互关系及辛伐他汀、氨氯地平对动脉粥样硬化进程中iNOS-NO的影响。方法 24只家兔予以高胆固醇饮食8周,8周后随机分为三组(n=8),三组均停用高胆固醇饮食,改普通饮食8周;模型组不用干预,另外两组分别喂饲辛伐他汀及氨氯地平进行药物干预。另取8只家兔予以普通饮食16周作为对照组。结果与对照组比较,模型组血脂水平明显升高,血清NO含量明显降低,iNOS表达明显升高(P均<0.01)。与模型组比较辛伐他汀组血浆TC、TG、LDL-C、ox-LDL-C下降明显(P<0.01),HDL-C升高(P<0.01);血清NO含量明显升高(P<0.01),iNOS表达明显减少(P<0.05)。而氨氯地平组血脂水平与模型组比较无统计学差异(P>0.05);血清NO含量亦无统计学差异(P>0.05),但iNOS表达明显减少(P<0.05)。结论动脉粥样硬化进程中,辛伐他汀、氨氯地平均可以通过下调血红素加氧酶/NO系统而延缓动脉粥样硬化进程。Objective To investigate the change rule of nitric oxide synthase（NOS）/nitric oxide（NO）and the influence of simvastatin and amlodipine on the system in atherosclerotic progress.Methods The rabbits received 1% cholesterol diet（n=24）for eight weeks;after eight weeks were fed with normal diet for eight weeks;one group（n=8）were administrated with simvastatin;one group（n=8）were administrated with amlodipine.Results Compared with the controt group,in model group the levels of serum lipids were increased obviously（P0.01）;however,the levels of serum nitric oxide and inducible nitric oxide synthase in aortic were decreased markedly（P0.01）.Compared with model group,in amlodipine group the levels serum lipids and serum nitric oxide were no significant effects（P0.05）,the expression of inducible nitric oxide synthase in aortic reduced greatly（P0.01）.Conclusions In atherosclerotic progress,simvastatin and amlodipine may delete atherosclerotic progress by decreasing the nitric oxide synthase（NOS）/nitric oxide（NO）system.

关 键 词：动脉粥样硬化 血红素氧化酶(脱环) 一氧化氧合酶 一氧化氮 氨氯地平 辛伐他汀 

分 类 号：R543[医药卫生—心血管疾病]