血浆线粒体偶联因子-6在冠心病患者冠脉循环中浓度的变化  

Change of level of plasma mitochondrial coupling factor-6 in coronary circulation of patients with coronary heart disease

作　　者：马健[1] 庞继恩[1] 

机构地区：[1]青岛解放军第401医院,山东青岛266071

出　　处：《心血管康复医学杂志》2011年第1期30-33,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究不同类型冠心病(CHD)[稳定型心绞痛(SAP)、不稳定型心绞痛(UAP)],以及急性心肌梗塞(AMI)]患者血浆线粒体偶联因子-6(MCF-6)在冠脉循环中浓度的变化。方法:用放免法分别测定不同类型心绞痛的冠心病患者与正常对照组外周、冠状静脉窦与主动脉根部血浆中MCF-6浓度,计算心脏局部分泌的MCF-6浓度(冠状静脉窦-主动脉根部浓度的差值)。结果:与正常对照组比较,CHD患者MCF-6浓度:外周[(294±40)pg/ml∶(265±40)pg/ml]、主动脉根部[(310±47)pg/ml∶(259±43)pg/ml]、冠状静脉窦[(384±42)pg/ml∶(271±37)pg/ml]、心脏局部分泌(74 pg/ml∶12pg/ml)的明显升高(P均<0.01),冠状静脉窦MCF-6浓度明显高于主动脉根部及外周循环的(P均<0.01);且在CHD患者,外周、主动脉根部与冠状静脉窦血浆中MCF-6浓度随CHD严重程度增加而明显升高,以AMI组患者最高(P均<0.01),分别为[(358±51)pg/ml,(366±48)pg/ml,(420±56)pg/ml]。结论:结果提示血浆线粒体偶联因子-6参与了冠心病的病理生理过程,在冠心病的发展过程中有可能是一种较为重要的血管活性物质。Objective：To investigate changes of level of plasma mitochondrial coupling factor 6（MCF-6） in coronary circulation of patients with coronary heart disease（CHD） [ contain stable angina pectoris（SAP）,unstable angina pectoris（UAP） and acute myocardial infarction（AMI）].Methods：Radioimmunoassay was used to measure concentrations of CF-6 in peripheral circulation,aortic root（Ao） and coronary sinus（CS） of CHD patients and normal control group.The CS-Ao difference of MCF-6 was regarded as concentration of MCF-6 secreted by local heart.Results：Concentrations of MCF-6 in CHD patients were significantly higher than those in normal control group in peripheral circulation [（294±40）pg/ml vs.（265±40） pg/ml],Ao [（310±47） pg/ml vs.（259±43） pg/ml],CS [（384±42） pg/ml vs.（271±37） pg/ml] and local heart（74 pg/ml vs.12pg/ml）,P0.01 all.The concentration of CF-6 in CS was significantly higher than those in peripheral circulation and Ao（P0.01 all）.Among CHD patients,concentrations of plasma CF-6 in peripheral circulation,Ao and CS increased along with the severity of CHD increased（P0.01 all）,and reached top in AMI patients [respectively were（358±51）pg/ml,（366±48）pg/ml,（420±56）pg/ml].Conclusion：The results indicate plasma mitochondrial coupling factor-6 may be involved in process of pathophysiology of coronary heart disease and may be one of important vasoactive agents in the development of coronary heart disease.

关 键 词：冠状动脉疾病 线粒体 心绞痛 

分 类 号：R541.409[医药卫生—心血管疾病]