疑诊冠心病患者中心动脉压与高敏性C反应蛋白的关系  

Association of central aortic pressure and high sensitivity C-reactive protein in patients with suspected coronary artery disease

作　　者：韩可[1] 陈漠水[1] 黄晓娇[1] 邢波[1] 杜子军[1] 陆士娟[1] 

机构地区：[1]中南大学湘雅医学院附属海口医院海口市人民医院心内科,海南海口市570208

出　　处：《心血管康复医学杂志》2011年第1期33-35,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：海南省海口市重点科技项目(2009-049)

摘　　要：目的：探讨中心动脉压与高敏C反应蛋白（hs-CRP）浓度之间关系。方法：入选疑诊冠心病患者101例,行冠脉造影,测量其中心动脉压力[按脉压分为：高脉压组（≥50mmHg）、中脉压组（40~49mmHg）及低脉压组（〈40mmHg）]、用间接测压法测量右上肢血压[分为高脉压组（≥60mmHg组）、中脉压组（50~59mmHg组）及低脉压组（〈50mmHg组）],采用酶联免疫法检测其血清hs-CRP水平。结果：hs-CRP水平随中心动脉脉压差的增大而明显上升[低脉压组（8.88±0.91）mg/L∶中脉压组（15.63±2.93）mg/L∶高脉压组（27.24±3.87）mg/L,P均〈0.05],且二者呈正相关（r=0.346,P〈0.01）;而在外周动脉高、中、低脉压组,hs-CRP水平各组间均无显著差异（P〉0.05）。结论：hs-CRP水平随中心动脉脉压差的增大而明显上升,炎症参与大血管病变的发生与发展。Objective：To explore the association of central aortic pressure（CAP） and high sensitivity C-reactive protein（hs-CRP） in patients with suspected coronary artery disease（CAD）.Methods：A total of 101 patients who were suspected as CAD were enrolled in the study.Central aortic pressure was measured by coronary angiography [divided into：high pulse pressure（PP）group（PP≥50mmHg）,medium PP group（PP=40～49mmHg）,low PP group（PP40 mmHg）according PP].Blood pressure of right upper limb was measured by indirect measurement method[high PP group（PP≥60mmHg）,medium PP group（50~59mmHg）,low PP group（50mmHg）]and serum level of hs-CRP was measured by enzyme linked immunosorbent assay.Results：Level of hs-CRP significantly increased along with PP of CAP increase [low PP group（8.88±0.91） mg/L vs.medium PP group（15.63±2.93） mg/L vs.high PP group（27.24 ±3.87） mg/L,P0.05 all,among three groups],the PP was positive correlated with hs-CRP（r=0.346,P0.01）.For peripheral aortic pressure,no significant difference existed among low PP group,medium PP group and high PP group（P0.05）.Conclusion：Level of hs-CRP significantly increased along with PP of central aortic pressure increase.It suggests inflammation takes part in the occurrence and development of lesions of large vessels.

关 键 词：血压 C反应蛋白质 冠状动脉疾病 

分 类 号：R972.4[医药卫生—药品]