国产药物洗脱支架在冠心病复杂病变中的应用研究  

Effect of homemade drug-eluting stent in the treatment of complicated coronary artery disease

作　　者：刘伶[1] 林英忠[1] 王风[1] 徐广马[1] 袁军[1] 黄宗燕[1] 林虹[1] 

机构地区：[1]广西壮族自治区人民医院心血管内科,南宁530021

出　　处：《岭南心血管病杂志》2011年第1期33-35,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨国产药物洗脱支架在冠状动脉粥样硬化性心脏病(冠心病)复杂病变患者中应用的安全性及临床疗效。方法将215例确诊为冠心病的患者分为3组:单枚支架植入组(n=75)、两支架植入组(n=72)和多枚(≥3枚)支架植入组(n=68),术后长期随访,观察术后12个月随访终点时支架内再狭窄发生率及主要心血管事件(包括死亡、急性心肌梗死、靶血管再成形等)发生率。结果 215例患者经皮冠状动脉介入治疗均成功。介入治疗12个月随访结果显示,多支架组与两支架组和单支架组比较,支架内再狭窄及主要心血管事件发生率比较,差异均无统计学意义(P>0.05)。结论多枚国产药物支架植入在复杂冠心病患者中应用安全、有效。Objectives To assess the efficacy and safety of implantation of homemade drug-eluting stents in patients with complicated coronary artery disease. Methods According to the stent number, 215 patients with coronary artery disease from March 2004 to March 2009 were divided into three groups： single stent group （OS group,n=75）;two stents group （TS group,n=72） ; ≥3 stents group （MS group,n=68）. The occurrence rate of in-stent restenosis （ISR） and major adverse cardiovascular event （sudden death, reinfarction, revascularization） were analysed after 12 months of implantation. Results Three groups showed a success rate of 100% in stenting. There were no statistic difference on aspect of ISR and on aspect of major adverse cardiovascular event （P〉0.05） after 12 months of implantation. Conclusions Implantation of multiple drug-eluting stents does not increase the risk of restenosis or major adverse cardiovascular event, and it is comparable safety and efficacy with implantation of single and two stents.

关 键 词：冠状动脉疾病 药物洗脱支架 支架内再狭窄 主要心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]