甲醇镁作用下合成水杨醛及其衍生物  

Synthesis of salicylaldehyde and related derivatives used by magnesium methoxide

作　　者：张家祥[1] 欧阳杰[1] 孙华东[1] 吕晓兰[1] 王春颖[1] 曹磊[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津理工大学学报》2011年第1期43-46,共4页Journal of Tianjin University of Technology

基　　金：国家自然科学基金(20771082);天津市自然科学基金(09JCYBJC05800)

摘　　要：以苯酚和带有取代基的苯酚为原料,在甲醇镁的作用下采用多聚甲醛进行甲酰化反应,合成了水杨醛、5-甲基水杨醛和3-甲酰基-4羟基苯甲酸乙酯.与传统的甲酰化方法相比,具有收率较高、产品纯度较高、原料廉价易得等优点,产物的结构经过IR和1H-NMR进行了表征.Salicylaldehyde,2-hydroxy-5-methylbenzaldehyde and ethyl-3-formyl-4-hydroxybenzoate were synthesized from phenol and substituted phenol.The hydroformylation were achieved by using magnesium methoxide and paraformaldehyde.Compared with the traditional reaction,the new method got many advantages,such as high yield,high purity and cheap raw materials.The structure of the products was characterized by IR and 1H-NMR.

关 键 词：甲醇镁 苯酚 水杨醛 5-甲基水杨醛 3-甲酰基-4羟基苯甲酸乙酯 

分 类 号：TQ244.1[化学工程—有机化工]